{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T12:07:46Z","timestamp":1781611666995,"version":"3.54.5"},"reference-count":25,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Aims:<\/i><\/b> To investigate the prevalence of sickle cell maculopathy (SCM), and associations with age, sex, genotype, proliferative sickle cell retinopathy (PSR) stage, and the impact on visual acuity. <b><i>Methods:<\/i><\/b> Age, sex, and visual acuity were recorded and spectral domain OCT and ultra-wide-field images of the macula and retina were reviewed in a consecutive series of 74 adults with sickle cell disease. <b><i>Results:<\/i><\/b> The median age was 37 years (range 19\u201373 years) and 36 cases (48.6%) were male. SCM was present in at least 1 eye of 40 cases (54.1%) or in 67 of all eyes (42.3%). SCM prevalence was 54.8%, 62.5%, and 25% for the <i>HbSS<\/i>, <i>HbSC<\/i>, and <i>HbS<\/i>\/<i>BTha<\/i>l or other genotypes, respectively. SCM was observed in 41 (39.4%) of the eyes with PSR stages 0, 1, and 2, and in 21 (51.2%) of the eyes with PSR stages 3, 4, and 5, respectively. Mild visual impairment or worse was present in 3 eyes (4.8%) with SCM but this was secondary to other pathology. <b><i>Conclusion:<\/i><\/b> SCM is a frequent finding in the eyes of adults with sickle cell disease. The prevalence is similar for the <i>HbSS<\/i> and <i>HbSC<\/i> genotypes and is not related to the PSR stage. High-contrast distance visual acuity is typically preserved. <\/jats:p>","DOI":"10.1159\/000512636","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T22:00:31Z","timestamp":1604008831000},"page":"159-164","source":"Crossref","is-referenced-by-count":11,"title":["Sickle Cell Maculopathy: Prevalence, Associations and Impact on Visual Acuity"],"prefix":"10.1159","volume":"244","author":[{"given":"Haroen","family":"Sahak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Saqalain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooi\u00a0Wah","family":"Lott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4388-243X","authenticated-orcid":false,"given":"Martin","family":"McKibbin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2009.11.004"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000423"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1971.00990050430006"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(78)90013-2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/BF01028533"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.12.010"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2011.03.035"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2014-305532"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0193582"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.08.010"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.02.007"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-312305"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000309"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2019.03.001"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.09.025"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.05.026"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S195168"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjo.2017.10.006"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2018.03.013"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-019-0499-7"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001230"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2015.12.023"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2019-314567"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1974.01010010469002"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2017.3008"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512636","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:05:02Z","timestamp":1745424302000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000512636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,29]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,5,5]]},"published-print":{"date-parts":[[2021,5,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000512636","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,29]]}}}