{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:52:14Z","timestamp":1787017934655,"version":"build-2736575974"},"reference-count":29,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Genomics"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Background:<\/i><\/b> We aimed to explore the relation of <i>XPD<\/i> and <i>XPF<\/i> variants with non-small cell lung cancer (NSCLC) risk and the effect of these variants on the sensitivity to cisplatin-based chemotherapy among the Chinese Han population in high-altitude areas. <b><i>Methods:<\/i><\/b> Eight single-nucleotide polymorphisms (SNPs) in <i>XPD<\/i> and <i>XPF<\/i> were genotyped by Agena MassARRAY platform among 506 NSCLC cases and 510 healthy controls. Correlation of <i>XPD<\/i> and <i>XPF<\/i> gene polymorphisms with NSCLC susceptibility and the response of cis\u00adplatin-based chemotherapy were analyzed with logistic regression by calculating odds ratios (ORs) and 95% confidence intervals (CIs). <b><i>Results:<\/i><\/b> <i>XPD<\/i> rs13181 (OR = 1.53, 95% CI: 1.04\u20132.24, <i>p<\/i> = 0.029) and rs1052555 (OR = 1.63, 95% CI: 1.05\u20132.53, <i>p<\/i> = 0.029) possibly contributed to the increased risk of lung adenocarcinoma, while <i>XPD<\/i> rs238406 (OR = 0.63, 95% CI: 0.43\u20130.94, <i>p<\/i> = 0.024) was a protective factor for lung squamous cell carcinoma. Age, gender, BMI, smoking, and drinking might affect the correlation of <i>XPD<\/i> and <i>XPF<\/i> polymorphisms with NSCLC risk. More importantly, <i>XPD<\/i> rs13181 (OR = 2.91, <i>p<\/i> = 0.015), <i>XPD<\/i> rs1052555 (OR = 2.67, <i>p<\/i> = 0.022), and <i>XPF<\/i> rs231127 (OR = 4.15, <i>p<\/i> = 0.008) were associated with treatment response in NSCLC patients underwent cisplatin-based chemotherapy. <b><i>Conclusion:<\/i><\/b> This study found that <i>XPD<\/i> and <i>XPF<\/i> variants might contribute to NSCLC risk and the response of cisplatin-based chemotherapy among the Chinese Han population in high-altitude areas.<\/jats:p>","DOI":"10.1159\/000512641","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T17:01:10Z","timestamp":1617814870000},"page":"189-198","source":"Crossref","is-referenced-by-count":8,"title":["Contribution of XPD and XPF Polymorphisms to Susceptibility of Non-Small Cell Lung Cancer in High-Altitude 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