{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T23:41:53Z","timestamp":1775518913029,"version":"3.50.1"},"reference-count":25,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Complement Med Res"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Dry eye disease (DED) has a higher incidence in old age and is seen predominantly in females worldwide. Neurosensory abnormalities, ocular surface inflammation and damage, film instability, and hyperosmolarity are major and proven pathologies responsible for a poor quality of life. Tear breakup time and Schirmer\u2019s I test are predominantly used for the evaluation of primary outcomes in patients undergoing conventional treatment. A previous meta-analysis of some relevant studies proved that combination of acupoints could be more effective than single acupoint treatment. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; The present study aimed to undertake association rule mining and examined the potential kernel acupoint combination in DED treatment constructed from the extracted randomized controlled trials (RCTs) based on a previous meta-analysis. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We summarized 32 acupoints as binary data from the 12 eligible RCTs and analyzed them based on the Apriori algorithm. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; TE23, BL2, ST2, ST1, EX-HN5, BL1, LI4, ST36, SP6, and KI3 were the 10 most frequently selected acupoints. The major associated rules in combination of acupoints were {TE23, LI4} \u2265 {ST1} and {TE23, ST1} \u2265 {LI4}, as inferred from 23 association rules. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; For acupuncture treatment of DED, combined TE23, LI4, and ST1 acupoints could be settled as the kernel of acupoint combination. <\/jats:p>","DOI":"10.1159\/000512674","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T22:01:47Z","timestamp":1608242507000},"page":"317-324","source":"Crossref","is-referenced-by-count":14,"title":["An Association Rule Analysis of Combined Acupoints for the Treatment of Patients with Dry Eye Disease"],"prefix":"10.1159","volume":"28","author":[{"given":"Ya-Hsuan","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsein-Chang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Chun","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I-Shiang","family":"Tzeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Ya","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5702-5730","authenticated-orcid":false,"given":"Chan-Yen","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.11.060"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2016.04.005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.06.033"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-0124(12)70081-2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.10.023"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2014.02.002"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2014.12.001"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/01.icu.0000512373.81749.b7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S33133"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2013.838557"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2013.02.002"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2020.8561"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/752194"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s10916-018-1125-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0000000000000042"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X03001661"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S175321"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011931"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27492007000300014"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2012-302705"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000000530"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071349"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.04.001"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/143858"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-018-2202-0"}],"container-title":["Complementary Medicine Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512674","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:05:33Z","timestamp":1745424333000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000512674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,17]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,8,24]]},"published-print":{"date-parts":[[2021,8,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000512674","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.13398965","asserted-by":"subject"}]},"ISSN":["2504-2092","2504-2106"],"issn-type":[{"value":"2504-2092","type":"print"},{"value":"2504-2106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,17]]}}}