{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T22:37:08Z","timestamp":1781217428711,"version":"3.54.1"},"reference-count":43,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Panic disorder (PD) has many comorbidities such as depression, bipolar disorder (BPD), and agoraphobia (AG). PD is a moderately heritable anxiety disorder whose pathogenesis is not well understood. Recently, a tri-allelic serotonin transporter (5-HTTLPR\/rs25531) polymorphism was reported to be more sensitive to personality traits compared to the bi-allelic 5-HTTLPR polymorphism. We hypothesized that the 5-HTTLPR\/rs25531 polymorphism may lead to a pathological anxious state depending on the presence or absence of a comorbidity in PD. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; In this study, we investigated the relationship between comorbidities in PD and tri-allelic 5-HTTLPR polymorphisms. A total of 515 patients with PD (148 males, 367 females) were genotyped, and the Revised NEO Personality Inventory as well as anxiety-related psychological tests were administered. Depression, BPD, and AG were diagnosed as comorbidities. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; For the tri-allele 5-HTTLPR genotype, a significant interaction effect was found between openness to experience and comorbid depression. Examination of the interaction between AG and the tri-allelic 5-HTTLPR genotype revealed that L\u2019 allele carriers are associated with higher trait anxiety than the S\u2019S\u2019 genotype group in PD without AG. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Some anxiety and personality traits can be characterized by the tri-allelic gene effect of 5-HTTLPR. These results suggest that tri-allelic 5-HTTLPR genotypes have genetic effects on the presence of comorbidities of PD. <\/jats:p>","DOI":"10.1159\/000512699","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T22:01:47Z","timestamp":1608242507000},"page":"333-341","source":"Crossref","is-referenced-by-count":10,"title":["Association of Serotonin Transporter Gene (5-HTTLPR\/rs25531) Polymorphism with Comorbidities of Panic Disorder"],"prefix":"10.1159","volume":"80","author":[{"given":"Shunsuke","family":"Tanahashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Tanii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Konishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Otowa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Tochigi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisanobu","family":"Kaiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiro","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1037\/0021-843X.110.4.585"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2010.01541.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/1520-6394(2000)12:1+<69::AID-DA9>3.0.CO;2-K"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.4.415"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.10.014"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/da.22277"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.30773\/pi.2018.07.26"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5618.2006.00356.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2018.08.035"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/gm161"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-017-0306-y"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1177\/026988119801200201"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/1096-8628(20001204)96:6<845::AID-AJMG30>3.0.CO;2-R"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2016.12.006"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5215.2008.00282.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000698"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.66062621.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5292.1527"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001789"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.190092"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2011.10.003"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1177\/0004867416637920"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2019.07.131"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2016.08.055"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30808"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2005.01408.x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.174.4.297"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1965.01720310065008"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(86)90143-9"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2013.04.024"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-013-1412-2"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1100757108"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000334"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2009.00092.x"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-11-50"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1037\/a0016198"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.12.001"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10187"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2017.07.071"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1002\/da.20450"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2016.05.014"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.593"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1002\/da.22885"}],"container-title":["Neuropsychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512699","content-type":"ap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