{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:26:54Z","timestamp":1781155614800,"version":"3.54.1"},"reference-count":42,"publisher":"S. Karger AG","issue":"7-8","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Introduction:<\/i><\/b> Limited evidence is available concerning experience with use of zoledronic acid (ZA) and treatment for conditions other than primary bone fragility. <b><i>Materials and Methods:<\/i><\/b> A retrospective review of all Royal Children Hospital patients who had been administered at least 1 dose of intravenous ZA from 2002 to 2015 was undertaken. <b><i>Results:<\/i><\/b> The audit included 309 children with 228 being treated for bone fragility conditions. Of the 228, 68 had height-adjusted lumbar spine bone mineral density Z-scores available over up to a 5-year period, and median increases were +2.0 SD (median absolute deviation = 0.9) (<i>N<\/i> = 36, <i>p<\/i> value for median increase of at least 0.5 in Z-score &#x3c;0.001), for patients with osteogenesis imperfecta or other primary bone fragility disorders, +1.0 SD (0.9) (<i>N<\/i> = 14, <i>p<\/i> = 0.029), for immobility conditions, +0.5 SD (0.7) (<i>N<\/i> = 10, <i>p<\/i> = 0.399), and for glucocorticoid-induced secondary osteoporosis, +0.7 SD (0.6) (<i>N<\/i> = 8, <i>p<\/i> = 0.015). 81\/309 children were treated for bone abnormality indications (e.g., avascular necrosis [AVN], fibrous dysplasia, and bone cysts). Of 39 with AVN, outcome data were available for 33, with joint integrity maintained for 24\/33 from 6 to 24 months after last ZA, subjective reports (22\/28) of reduced pain. Reduction in bone lesion size was seen in 2\/4 patients with bone cysts within 12 months of ZA commencement. <b><i>Discussion\/Conclusion:<\/i><\/b> This is the largest cohort of reported outcomes of ZA use in a paediatric population. Results demonstrate a good efficacy profile and associated improved bone density for osteoporotic conditions and stabilization of non-traumatic AVN with a low rate of joint collapse. <\/jats:p>","DOI":"10.1159\/000512730","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T22:00:41Z","timestamp":1611871241000},"page":"442-452","source":"Crossref","is-referenced-by-count":9,"title":["Outcomes of Zoledronic Acid Use in Paediatric Conditions"],"prefix":"10.1159","volume":"93","author":[{"given":"Angelina","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Simm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6354-5882","authenticated-orcid":false,"given":"Samantha 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