{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T21:41:38Z","timestamp":1780350098713,"version":"3.54.1"},"reference-count":29,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Background:<\/i><\/b> Literature focusing on nutritional variables and survival in interstitial lung disease (ILD) is limited by its focus on weight and BMI and has not considered body composition. <b><i>Objectives:<\/i><\/b> The primary objective of this study was to examine whether body composition measures, specifically fat-free mass index z-score (z-FFMI) and body fat mass index z-score (z-BFMI), were predictors of survival in fibrotic ILD patients. The second objective was to examine if nutrition status was a predictor of survival. <b><i>Method:<\/i><\/b> Seventy-eight outpatients diagnosed with fibrotic ILD were recruited in this cross-sectional study. Body composition data using dual frequency bioelectrical impedance analysis (BodyStat 1500MD; UK) and nutrition status using the subjective global assessment (SGA) were determined. To control for age and sex, z-FFMI and z-BFMI were calculated using population means. Participant charts were reviewed for diagnosis, age, disease severity, and exercise capacity. <b><i>Results:<\/i><\/b> Age (HR 1.08, 95% CI [1.03\u20131.13], <i>p<\/i> &#x3c; 0.01), BMI (HR 0.90, 95% CI [0.84\u20130.97], <i>p<\/i> &#x3c; 0.01]), z-FFMI (HR 0.70, 95% CI [0.56\u20130.87], <i>p<\/i> = 0.02), z-BFMI (HR 0.74, 95% CI [0.57\u20130.96], <i>p<\/i> &#x3c; 0.01), 6-min walk distance (6MWD) (HR 0.99, 95% CI [0.99\u20131.00], <i>p<\/i> &#x3c; 0.01), percent predicted diffusing capacity for carbon monoxide (%DLco) (HR 0.93, 95% CI [0.89\u20130.97], <i>p<\/i> &#x3c; 0.01), and severe malnutrition (SGA-C) (HR 6.98, 95% CI [2.00\u201324.27], <i>p<\/i> &#x3c; 0.01) were significant predictors of survival. When controlled for exercise capacity and disease severity, z-FFMI and severe malnutrition were significant predictors of survival independent of %DLco. <b><i>Conclusion:<\/i><\/b> z-FFMI and severe malnutrition were significant predictors of survival in fibrotic ILD patients independent of disease severity. <\/jats:p>","DOI":"10.1159\/000512732","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T21:04:59Z","timestamp":1617051899000},"page":"379-386","source":"Crossref","is-referenced-by-count":22,"title":["Fat-Free Mass Index Controlled for Age and Sex and Malnutrition Are Predictors of Survival in Interstitial Lung Disease"],"prefix":"10.1159","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5454-2986","authenticated-orcid":false,"given":"Sylvia","family":"Rinaldi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Gilliland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"O\u2019Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie A.","family":"Seabrook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2159-7083","authenticated-orcid":false,"given":"Marco","family":"Mura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Madill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,3,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2007.11.008"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200211-1311OC"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2784"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn.82.1.53"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000014373"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12941"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12133"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1177\/014860718701100108"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/0148607107031005406"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-147OC"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201807-1255ST"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.3.7663792"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199708000-00009"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00279602"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/s0899-9007(01)00555-x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2004.08.012"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00106011"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000490355"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01289-2018"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200506-969OC"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2018-0276"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2015.03.001"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1177\/0115426504019006587"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2016.03.020"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/imj.13935"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.071399"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2018.12.008"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1159\/000506520"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512732","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512732","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:06:25Z","timestamp":1745424385000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000512732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":29,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,5,5]]},"published-print":{"date-parts":[[2021,5,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000512732","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}