{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:26:28Z","timestamp":1745468788917,"version":"3.40.4"},"reference-count":25,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T00:00:00Z","timestamp":1604361600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Background:<\/i><\/b> Previous studies have indicated that Sirtuin 1 (Sirt1) plays an important role in suppressing inflammatory responses in many diseases. However, the Sirt1 levels and role of Sirt1 in ocular Beh\u00e7et\u2019s disease (OBD) have not been fully elucidated. <b><i>Objective:<\/i><\/b> The objective of this study was to investigate the role of Sirt1 in the pathogenesis of OBD. <b><i>Methods:<\/i><\/b> Sirt1 and cytokine levels were measured using ELISA. Cell viability was determined using the Cell Counting Kit-8. The frequencies of Th17 and Th22 cells were detected using flow cytometry. <b><i>Results:<\/i><\/b> We found decreased expression of Sirt1 in CD4<sup>+<\/sup> T cells obtained from patients with active OBD. SRT1720, an agonist of Sirt1, significantly upregulated Sirt1 expression in CD4<sup>+<\/sup> T cells from patients with active OBD. Sirt1 activation by SRT1720 significantly suppressed the production of interleukin (IL)-17 and IL-22 by CD4<sup>+<\/sup> T cells and inhibited the expansion of Th17 and Th22 cells. <b><i>Conclusion:<\/i><\/b> Our results suggest that decreased Sirt1 expression might be involved in the pathogenesis of OBD and that activation of Sirt1 might be considered a potential target for OBD. <\/jats:p>","DOI":"10.1159\/000512754","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T22:00:33Z","timestamp":1604440833000},"page":"554-560","source":"Crossref","is-referenced-by-count":2,"title":["Decreased Expression of Sirt1 Contributes to Ocular Beh\u00e7et\u2019s Disease Progression via Th17 and Th22 Response"],"prefix":"10.1159","volume":"64","author":[{"given":"Manyun","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2020,11,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.04.056"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2012.723112"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1390"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059009"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2011.102"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.4.110807.092250"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2010.09.005"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38902"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600244"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2008.07.011"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-015-1332-9"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.01.011"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1042\/bsr20180541"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37027-2"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2014-0474OC"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.03.006"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1105304109"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.163667"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202677"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1084\/jem.2013237805062015c"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.527531"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.211219"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-216473"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00308.2006"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200708-1269OC"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512754","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512754","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:06:42Z","timestamp":1745424402000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000512754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,3]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,8,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000512754","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"type":"print","value":"0030-3747"},{"type":"electronic","value":"1423-0259"}],"subject":[],"published":{"date-parts":[[2020,11,3]]}}}