{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:19:42Z","timestamp":1790471982512,"version":"4.1.0"},"reference-count":18,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Background:<\/i><\/b> Digital fluoroscopic tomosynthesis-guided electromagnetic navigational bronchoscopy (F-ENB) is a novel adjunct to ENB associated with higher diagnostic yield. The likelihood of F-ENB allowing accurate placement of a biopsy needle within a target remains unclear. <b><i>Objective:<\/i><\/b> This study intends to determine the accuracy of F-ENB as confirmed by cone-beam computed tomography (CBCT) scan. <b><i>Methods:<\/i><\/b> Patients undergoing CBCT-assisted ENB for lung nodule biopsy were prospectively enrolled. ENB was performed followed by digital tomosynthesis correction. Once optimal F-ENB alignment was achieved, and a needle was advanced into the expected location of the nodule followed by CBCT. The primary outcome was the percentage of \u201cneedle-in-lesion\u201d hits, defined as needle tip within the nodule in 3 planes. Secondary outcomes were diagnostic yield, procedure and room time, complications, radiation, and distance between the needle tip and nodule. <b><i>Results:<\/i><\/b> Twenty-six patients with a total of 29 nodules were enrolled. Mean nodule size was 13 mm (\u00b14 mm) in maximal axial dimension, 83% (<i>n<\/i> = 24) were located in the peripheral third of the chest, and 17% (<i>n<\/i> = 5) had a bronchus sign. F-ENB guidance resulted in needle-in-lesion in 21 of 29 nodules (72%). Mean needle tip-to-nodule distance for nonhits was 1.75 mm (\u00b11.35 mm). There were no complications. <b><i>Conclusion:<\/i><\/b> F-ENB resulted in a needle-in-lesion biopsy in greater than 70% of nodules despite features traditionally associated with poor diagnostic yield (size, absence of bronchus sign). Mean distance between needle tip and target for nonhits was less than 2 mm. These data suggest F-ENB alignment is accurate for small peripheral nodules. <\/jats:p>","DOI":"10.1159\/000512802","type":"journal-article","created":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T02:02:24Z","timestamp":1612663344000},"page":"214-221","source":"Crossref","is-referenced-by-count":16,"title":["High Accuracy of Digital Tomosynthesis-Guided Bronchoscopic Biopsy Confirmed by Intraprocedural Computed Tomography"],"prefix":"10.1159","volume":"100","author":[{"given":"James","family":"Katsis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance","family":"Roller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3680-4372","authenticated-orcid":false,"given":"Joyce","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Lentz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otis","family":"Rickman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Maldonado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,2,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1102873"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1911793"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2072-1439.2015.12.16"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-155-3-201108020-00003"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-016-4357-8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000355710"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-1764"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2018.11.013"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201507-1332OC"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-1425"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2020.01.35"},{"key":"ref12"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0000000000000536"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0000000000000546"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.11.21"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201711-856OC"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007517"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-007-0212-y"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512802","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:07:10Z","timestamp":1745424430000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000512802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3,11]]},"published-print":{"date-parts":[[2021,3,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000512802","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}