{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T16:40:48Z","timestamp":1771260048346,"version":"3.50.1"},"reference-count":31,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Herpesviruses might play a role in the pathogenesis of neurodegenerative disorders. We sought to examine a possible association between alpha herpesvirus infections and Parkinson\u2019s disease. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We conducted a population-based case-control study of incident Parkinson\u2019s disease in 2009 Medicare beneficiaries age 66\u201390 years (89,790 cases, 118,095 randomly selected comparable controls). We classified beneficiaries with any diagnosis code for \u201cherpes simplex\u201d and\/or \u201cherpes zoster\u201d in the previous 5 years as having had the respective alpha herpesviruses. In beneficiaries with Part D prescription coverage, we also identified those prescribed anti-herpetic medications. We calculated odds ratios (OR) and 95% CI between alpha herpesvirus diagnosis\/treatment and Parkinson\u2019s disease with logistic regression, with adjustment for age, sex, race\/ethnicity, smoking, and use of medical care. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Parkinson\u2019s disease risk was inversely associated with herpes simplex (OR 0.79, 95% CI 0.74\u20130.84), herpes zoster (OR 0.88, 95% CI 0.85\u20130.91), and anti-herpetic medications (OR 0.87, 95% CI 0.80\u20130.96). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Herpesvirus infection or treatment might reduce risk of Parkinson\u2019s disease, but future studies will be required to explore whether this inverse association is causal. <\/jats:p>","DOI":"10.1159\/000512874","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T22:00:38Z","timestamp":1611007238000},"page":"97-103","source":"Crossref","is-referenced-by-count":27,"title":["Herpesvirus Infections and Risk of 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