{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:33:34Z","timestamp":1792701214827,"version":"4.5.0"},"reference-count":13,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Introduction:<\/i><\/b> Anal fistulae have a significant impact on the quality of life of patients with Crohn\u2019s disease (CD). In this cross-sectional study, we aimed to determine whether biological agents were effective in treating anal fistulae in patients with CD. <b><i>Methods:<\/i><\/b> Fifty-three patients diagnosed with CD were retrospectively enrolled. Their data regarding symptoms, treatments, and disease progression from January 2007 to December 2016 were reviewed from the medical records. Fifteen (28%) patients with CD were complicated by anal fistulae. <b><i>Results:<\/i><\/b> The male-to-female ratio was 13:2, and the mean age at onset was 11 years and 6 months. Among the 15 patients, 14 (93%) had anal fistulae as an initial symptom. Almost all patients were treated by providing elemental diet, 5-aminosalicylic acid, and steroids as induction therapy. Biological agents were used in 8 patients (53.3%), and fistula closure was confirmed in all of them. Among the 7 patients not treated with biological agents, 1 (14.3%) had a recurrent anal fistula, while another had incomplete fistula closure. Regarding surgical management, 2 patients were treated using the seton method, and no patients required a colostomy. <b><i>Conclusion:<\/i><\/b> Treatment with biological agents is highly effective concerning the closure of anal fistulae in patients with CD, and reducing pain may improve their quality of life. <\/jats:p>","DOI":"10.1159\/000512900","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T22:00:41Z","timestamp":1611266441000},"page":"783-788","source":"Crossref","is-referenced-by-count":2,"title":["Effectiveness of Biological Agents in the Treatment of Pediatric Patients with Crohn\u2019s Disease and Anal Fistulae"],"prefix":"10.1159","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7276-8201","authenticated-orcid":false,"given":"Nobuyasu","family":"Arai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Kudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhide","family":"Tokita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Kyodo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamichi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Miyata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Hosoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamaki","family":"Ikuse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Jimbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Ohtsuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep1340"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181a70f21"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21493"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804647"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)90999-j"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91375-v"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199905063401804"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.12.003"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/01.mpg.0000237933.38223.da"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2010.01731.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.03263.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2014.04.005"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61302-7"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512900","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512900","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:08:34Z","timestamp":1745424514000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000512900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":13,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,9,1]]},"published-print":{"date-parts":[[2021,9,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000512900","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}