{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:52:08Z","timestamp":1792007528561,"version":"4.4.0"},"reference-count":36,"publisher":"S. Karger AG","issue":"7","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; The stratum corneum contains several growth factors and cytokines that are synthesized in keratinocytes. We previously reported that the amount of interleukin-8 in the stratum corneum (scIL-8) is related to the severity of local skin inflammation in atopic dermatitis (AD). However, it is unknown whether scIL-8 levels reflect pharmacologic responses to a therapeutic intervention in AD patients. Therefore, in this study, we aimed to investigate whether the improvement of dermatitis in AD is correlated with scIL-8 levels before and after topical corticosteroid treatment. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Stratum corneum samples were collected from 22 AD patients using the noninvasive tape-stripping method before treatment, 2 weeks after topical treatment, and 4\u20136 weeks after treatment. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; scIL-8 levels on the forearm reduced significantly from 790 \u00b1 348 pg\/mg before treatment to 163 \u00b1 68 pg\/mg 2 weeks after treatment and 100 \u00b1 37 pg\/mg 4\u20136 weeks after corticosteroid treatment. scIL-8 levels on the abdomen also reduced significantly from 902 \u00b1 391 to 142 \u00b1 38 pg\/mg at the end of study. The reduction in scIL-8 levels was associated with the improvement in local skin severity in AD. We also found that scIL-8 levels, along with blood biomarker levels (serum thymus and activation-regulated chemokine, lactate dehydrogenase, and %eosinophil), decreased significantly after the treatment. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The scIL-8 concentration decreases with improvements in skin symptoms in AD patients after topical corticosteroid treatment; thus, it may be a suitable biomarker for monitoring therapeutic effects in AD patients.<\/jats:p>","DOI":"10.1159\/000512965","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T17:01:36Z","timestamp":1611334896000},"page":"592-606","source":"Crossref","is-referenced-by-count":38,"title":["Interleukin-8 Levels in the Stratum Corneum as a Biomarker for Monitoring Therapeutic Effect in Atopic Dermatitis Patients"],"prefix":"10.1159","volume":"182","author":[{"given":"Susumu","family":"Murata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakae","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eishin","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,1,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15048"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0138"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2006.00072.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00774.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000198"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2009.02908.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0846.2001.70405.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2004.02.001"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02361.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000327556"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000339666"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14891"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.03.023"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2011.01286.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17088"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16994"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000448400"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.7.799"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-011-1198-9"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/jcm4030479"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2003.01803.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.2983"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09342.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07632.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2007.00242.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.6.1883"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.4.1364"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.5.1547"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1126\/science.2648569"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/2.6.479"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/BF00373374"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12523566"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12514689"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12556058"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1159\/000484406"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.02.1228"}],"container-title":["International 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