{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:55:12Z","timestamp":1793040912720,"version":"4.5.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Pulmonary hypertension (PH) is the major pathophysiologic consequence of congenital diaphragmatic hernia (CDH). We aimed to evaluate the association between early CDH-associated PH (CDH-PH) and inpatient outcomes. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The CDH Study Group registry was queried for infants born 2015\u20132019 with echocardiograms before 48h of life. PH was categorized using echocardiographic findings: none, mild (right ventricular systolic pressure &amp;#x3c;2\/3 systemic), moderate (between 2\/3 systemic and systemic), or severe (supra-systemic). Univariate and multivariate analyses were performed. Adjusted Poisson regression was used to assess the primary composite outcome of mortality or oxygen support at 30 days. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Of 1,472 patients, 86.5% had CDH-PH: 13.9% mild (&lt;i&gt;n&lt;\/i&gt; = 193), 44.4% moderate (&lt;i&gt;n&lt;\/i&gt; = 631), and 33.2% severe (&lt;i&gt;n&lt;\/i&gt; = 468). On adjusted analysis, the primary outcome of mortality or oxygen support at 30 days occurred more frequently in infants with moderate (incidence rate ratio [IRR] 1.8, 95% confidence interval [CI], 1.2\u20132.6) and severe CDH-PH (IRR 2.0, 95% CI, 1.3\u20132.9). Extracorporeal life support (ECLS) utilization was associated only with severe CDH-PH after adjustment (IRR 1.8, 95% CI, 1.0\u20133.3). &lt;b&gt;&lt;i&gt;Discussion\/Conclusion:&lt;\/i&gt;&lt;\/b&gt; Early, postnatal CDH-PH is independently associated with increased risk for mortality or oxygen support at 30 days and utilization of ECLS. Early echocardiogram is a valuable prognostic tool for early, inpatient outcomes in neonates with CDH. <\/jats:p>","DOI":"10.1159\/000512966","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T21:03:59Z","timestamp":1618347839000},"page":"147-154","source":"Crossref","is-referenced-by-count":64,"title":["Early, Postnatal Pulmonary Hypertension Severity Predicts Inpatient Outcomes in Congenital Diaphragmatic Hernia"],"prefix":"10.1159","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4081-4215","authenticated-orcid":false,"given":"Dalya Munves","family":"Ferguson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4625-7413","authenticated-orcid":false,"given":"Vikas S.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela A.","family":"Lally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7698-8065","authenticated-orcid":false,"given":"Matias","family":"Luco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1223-6980","authenticated-orcid":false,"given":"KuoJen","family":"Tsao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin P.","family":"Lally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7296-6731","authenticated-orcid":false,"given":"Neil","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8929-8311","authenticated-orcid":false,"given":"Matthew T.","family":"Harting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for The Congenital Diaphragmatic Hernia Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2017.04.008"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2016.2023"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2019.07.006"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2003.11.010"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.12.036"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000329"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh090"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr183"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.08.014"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00336"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.10.024"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.170206"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000499347"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201904-0731OC"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s11936-019-0711-x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000002318"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2018.08.057"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-018-1850-7"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13464"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.11.012"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.09.010"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000399.pub3"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512966","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/512966","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:09:37Z","timestamp":1745424577000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000512966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,6,3]]},"published-print":{"date-parts":[[2021,6,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000512966","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.14406989","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}