{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:45:21Z","timestamp":1791938721529,"version":"4.3.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Pharmacol Physiol"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>Acne vulgaris (AV) is a very common inflammatory dermatosis. It has a complex pathogenesis in which oxidative stress plays an important role. Neutrophil cytosolic factor (NCF)-1 gene encodes for NCF1 protein which shares in reactive oxygen species (ROS) production. Copy number variation (CNV) is a type of genetic variance in which gene copies are duplicated or deleted. The current work aimed to detect the association between NCF1 CNV and NCF-1 genotypes and AV to explore their possible role in increased disease risk or influencing its clinical presentation. Twenty-five cases with AV and 25 age- and gender-matched healthy volunteers were selected. NCF1 CNV and genotypes were determined using quantitative real-time polymerase chain reaction. NCF1 copy number was significantly increased in patients compared to the control group (&lt;i&gt;p&lt;\/i&gt; = 0.02). Higher copy number increased the risk of occurrence of AV by about 4-fold. The NCF1 genotype was more prevalent in patients (72%) compared to NCF1B (24%) and NCF1C (4%) variants, while NCF1B and NCF1C variants (68%) were more prevalent in the control group. The NCF1B genotype decreased the risk of occurrence of AV by 0.2-fold. NCF1 was significantly associated with cases more than controls (&lt;i&gt;p&lt;\/i&gt; = 0.005). It increased the risk of occurrence of acne by 5.4-fold. There was significant association between NCF1 copy number and disease duration where higher number was associated with long disease duration (&lt;i&gt;p&lt;\/i&gt; = 0.03). Higher copy number was also associated with the NCF1 genotype (&lt;i&gt;p&lt;\/i&gt; = 0.01). This study suggests that increased copy number of NCF1 gene may be a predisposing factor for AV development. However, the presence of NCF1B and NCF1C variants lowers ROS production and subsequently decreases the risk of development of AV. <\/jats:p>","DOI":"10.1159\/000513053","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T10:35:40Z","timestamp":1613730940000},"page":"51-56","source":"Crossref","is-referenced-by-count":7,"title":["Neutrophil Cytosolic Factor-1 Genotyping in Acne Vulgaris"],"prefix":"10.1159","volume":"34","author":[{"given":"Ola","family":"Bakry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Shoeib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimaa","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamiaa","family":"Kamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12366"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60321-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.290"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2010.3440"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2156-11-13"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2008.02.005"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7231-9_9"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211287"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3782"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2010.1053"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242601"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1042\/CS20140635"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1113251108"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004801"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3192"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/nature17950"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.03.005"}],"container-title":["Skin Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513053","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:10:15Z","timestamp":1745424615000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000513053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,3,15]]},"published-print":{"date-parts":[[2021,3,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000513053","archive":["Portico"],"relation":{},"ISSN":["1660-5527","1660-5535"],"issn-type":[{"value":"1660-5527","type":"print"},{"value":"1660-5535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}