{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T22:47:20Z","timestamp":1769208440003,"version":"3.49.0"},"reference-count":12,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Background:<\/i><\/b> Haemorrhagic and thrombotic complications are common in dialysis patients on warfarin; thus, accurate international normalized ratio (INR) monitoring is critical. For expediency and patient comfort, blood sampling from the haemodialysis access or circuit is commonly performed. Point-of-care (POC) INR machines allow both peripheral vein preservation and rapid results, yet are not validated in the haemodialysis population. <b><i>Methods:<\/i><\/b> A prospective cohort study in haemodialysis patients taking warfarin was undertaken. Three paired samples were drawn over a single session: peripheral blood INR, POC INR, and dialysis INR. Agreement using Bland-Altman analysis and correlation coefficients between the peripheral blood INR, haemodialysis INR, and POC INR were calculated. Inappropriate dosing decisions based on haemodialysis or POC INR were quantified. <b><i>Results:<\/i><\/b> Amongst 34 patients, agreement between the dialysis INR and peripheral blood INR was high, with the haemodialysis INR differing from the peripheral INR by &#x3c;\u00b10.2, 85.2% of the time. Correlation between the 2 methods was high (<i>r<\/i> = 0.914; <i>p<\/i> &#x3c; 0.001). POC INR differed from peripheral INR values by &#x3c;\u00b10.2, 67.6% of the time, with less agreement at higher INR values. Dosing decisions were incongruent between the dialysis and peripheral INR in 6%, whilst the POC and peripheral INR disagreed in 26%. <b><i>Conclusions:<\/i><\/b> There was good agreement and correlation between the peripheral blood, haemodialysis access\/circuit, and POC INR values. POC INR was less reliable at higher values, and dosing decisions differed from the peripheral INR in a quarter of cases. <\/jats:p>","DOI":"10.1159\/000513094","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T22:05:07Z","timestamp":1612821907000},"page":"17-25","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of Sampling Methods for International Normalized Ratio Monitoring in Haemodialysis Patients (INRHaemo Study)"],"prefix":"10.1159","volume":"52","author":[{"given":"Theepika","family":"Rajkumar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lachlan","family":"Weidersehn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Surmon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Makris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,2,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/170576"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-016-0368-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu334"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.5414\/CP201779"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e31826f34f3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008070802"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v120.21.3170.3170"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2200"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04568.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03360708"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/112972980901000308"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2008.04.021"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513094","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:10:38Z","timestamp":1745424638000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000513094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,3,22]]},"published-print":{"date-parts":[[2021,3,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000513094","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}