{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T21:04:26Z","timestamp":1770066266038,"version":"3.49.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Background:<\/i><\/b> Endothelial dysfunction is a predictor of atherosclerotic cardiovascular disease (ASCVD) and plays an important role in vasospastic angina (VA). <b><i>Objectives:<\/i><\/b> This study evaluated whether flow-mediated dilation (FMD) is also a good marker of 10-year ASCVD risk (10Y-ASCVDR) in patients with VA. <b><i>Methods:<\/i><\/b> Based on their clinical history and coronary artery diameter stenosis (DS), patients were retrospectively enrolled into VA (DS &#x3c;50% and positive ergonovine provocation), minor coronary artery disease (mCAD, DS &#x3c;30%), and significant coronary artery disease (sCAD, DS \u226550%) groups. Endothelial function was evaluated by FMD. <b><i>Results:<\/i><\/b> Each group contained 50 patients. The 10Y-ASCVDR was significantly higher in the sCAD group than in the VA and mCAD groups (10.86 \u00b1 7.30, 4.71 \u00b1 4.04, and 4.77 \u00b1 4.30, respectively, <i>p<\/i> &#x3c; 0.001). The FMD was significantly higher in the mCAD group than in the VA and sCAD groups (6.37 \u00b1 4.25, 3.10 \u00b1 2.23, and 3.07 \u00b1 1.89, respectively, <i>p<\/i> &#x3c; 0.001). A significant correlation was found between the FMD and 10Y-ASCVD in the mCAD group (<i>r<\/i> = \u22120.622, <i>p<\/i> &#x3c; 0.001) and the sCAD group (<i>r<\/i> = \u22120.557, <i>p<\/i> &#x3c; 0.001) but not in the VA group (<i>r<\/i> = \u22120.193, <i>p<\/i> = 0.179). After adjusting for potential confounders such as BMI, C-reactive protein, maximal coronary stenosis, and brachial-ankle pulse wave velocity, multivariate analysis showed that FMD was independently associated with 10Y-ASCVDR in all patients. However, when looking only at the VA group, FMD did not correlate independently with 10Y-ASCVDR. <b><i>Conclusions:<\/i><\/b> Unlike mCAD and sCAD, we found no correlation between 10Y-ASCVDR and endothelial function in VA. Thus, our results support that FMD is not a good marker of atherosclerotic cardiovascular risk in VA. <\/jats:p>","DOI":"10.1159\/000513141","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T21:03:59Z","timestamp":1618347839000},"page":"281-287","source":"Crossref","is-referenced-by-count":3,"title":["Association between 10-Year Atherosclerotic Cardiovascular Disease Risk and Vascular Endothelial Function in Patients with Vasospastic Angina"],"prefix":"10.1159","volume":"146","author":[{"given":"Kyoung-Ha","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo Jung","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Sook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Ho","family":"Jo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Ai","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Mi","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Won","family":"Suh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj-08-1102"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000025404.78001.d8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)93147-f"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000067881.26274.BD"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(94)90141-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000095273.92468.D9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000153339.27064.14"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(97)00236-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.99.22.2864"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0000000000000721"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000437741.48606.98"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj-66-0098"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpz100"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(59)90003-8"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-15-0520"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000362380"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1988.tb10306.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(98)00520-8"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(00)00729-4"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1042\/cs20010144"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.26.615"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.25.359"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200103000-00005"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(88)90804-6"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(95)00088-l"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(99)00073-x"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513141","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:11:06Z","timestamp":1745424666000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000513141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,5,17]]},"published-print":{"date-parts":[[2021,5,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000513141","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}