{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:20:30Z","timestamp":1788222030147,"version":"build-2803163510"},"reference-count":14,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Gastroenterol"],"abstract":"<jats:p>Eosinophilic colitis (EC) belongs to a group of idiopathic diseases called eosinophilic gastrointestinal disorders, which are characterized by eosinophil-predominant inflammation in the gastrointestinal tract. Corticosteroids is the first-line pharmacotherapy for EC refractory to diet therapy. We report an infant with steroid-resistant EC, who successfully returned to a healthy growth trajectory under the combined therapy of montelukast and ketotifen. An 8-month-old boy presented with bloody diarrhea, anemia, and failure to thrive (FTT) that started 6 days after birth. The patient has no known allergies. A trial of elementary diet was unsuccessful. The results of several stool cultures were unremarkable. Similarly, lower gastrointestinal series failed to identify anything significant. At 3 months of age, an esophagogastroduodenoscopy with biopsies from the distal duodenum and proximal jejunum were unremarkable. The diarrhea and FTT persisted. A rectosigmoidoscopy with biopsies was performed; the results led to the diagnosis of EC at 5 months of age. Oral prednisolone 1 mg\/kg\/day was prescribed; however, 3 months into the treatment, persistent bloody diarrhea and FTT were still noted. Montelukast and ketotifen were added, after which diarrhea and weight gain started to improve. Prednisolone and montelukast\/ketotifen were tapered off 6 months after. He remains symptom free and has normal growth and development in a 5-year follow-up. <\/jats:p>","DOI":"10.1159\/000513146","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T16:26:21Z","timestamp":1616516781000},"page":"389-394","source":"Crossref","is-referenced-by-count":7,"title":["Successful Montelukast Treatment in an Infant with Steroid-Resistant Eosinophilic Colitis"],"prefix":"10.1159","volume":"15","author":[{"given":"Nai-Wei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsuan","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Jong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,3,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.10.047"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldr045"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/s12948-016-0055-y"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.127663"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2019.04.011"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X10392443"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200001001-00009"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-016-4203-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200403000-00021"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.03029.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200059001-00006"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2011.06.006"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-5-24"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2011.03.008"}],"container-title":["Case Reports in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513146","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:11:12Z","timestamp":1745424672000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000513146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,18]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,5,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000513146","archive":["Portico"],"relation":{},"ISSN":["1662-0631"],"issn-type":[{"value":"1662-0631","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,18]]}}}