{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T21:12:36Z","timestamp":1766869956287,"version":"3.40.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Nutr Metab"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Background:<\/i><\/b> Previous studies have demonstrated the close relationship between vitamin D, vitamin D receptor (VDR), and obesity. Nevertheless, few studies have reported wherther the relationship among these is associated with the risk of cardiovascular diseases (CVDs) in Chinese children and adolescents. <b><i>Objective:<\/i><\/b> The present study aimed to reveal the effects of obesity, serum vitamin D levels, and VDR <i>FokI<\/i> genotype on the risk of CVDs in children and adolescents in Sichuan, China. <b><i>Methods:<\/i><\/b> Children and adolescents were recruited into a cross-sectional study. Serum vitamin D levels, serum lipid levels, and VDR <i>FokI<\/i> gene polymorphisms were measured in the laboratory. The selected lipid factors were used as biomarkers of CVD risk. The impact of obesity, vitamin D levels and VDR <i>FokI<\/i> genotype on CVD risk factors were investigated. <b><i>Results:<\/i><\/b> Higher lipid levels were observed in children and adolescents in the obese group, when compared to the nonobese group. In the obese group, the C allele carriers had significantly lower concentrations of lipids, when compared to the TT genotype. C allele carriers who were vitamin D deficient had lower levels of total cholesterol (TC), triglycerides (TG), apolipoprotein B (Apo-B), total cholesterol\/high-density lipoprotein cholesterol (TC\/HDL-C), low-density lipoprotein cholesterol\/high-density lipoprotein cholesterol (LDL-C\/HDL-C), and triglycerides\/high-density lipoprotein cholesterol (TG\/HDL-C), when compared to those with the TT genotype in obese children and adolescents. For vitamin D-insufficient obese children and adolescents, the TC, Apo-B, and TC\/HDL-C in the C allele carriers were significantly lower, when compared to those in the TT genotype in obese children and adolescents. <b><i>Conclusion:<\/i><\/b> Obese children with low vitamin D levels, who are carriers of the C allele of the <i>FokI<\/i> gene, have lower levels of several biochemical markers of CVD risk, when compared to those who were TT homozygous. Obese children and adolescents may benefit from vitamin D supplementation, terms of lowering their CVD risk, particularly when they are carriers of the C allele of the <i>FokI<\/i> gene. <\/jats:p>","DOI":"10.1159\/000513287","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T16:06:13Z","timestamp":1616515573000},"page":"396-404","source":"Crossref","is-referenced-by-count":7,"title":["Impact of Vitamin D and Vitamin D Receptor on Risk of Cardiovascular Diseases in Children and Adolescents with Obesity in Sichuan, China: A Cross-Sectional Study"],"prefix":"10.1159","volume":"76","author":[{"given":"Hongjian","family":"Xie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Min","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siqi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Xian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yali","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,2,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9121302"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00336.2004"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000449"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7293861"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2174\/1573403X14666180222102312"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2010.04.005"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1186\/s40885-018-0094-4"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.03.047"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2007.08.023"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317727164"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.1.18"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2007.12.001"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12420"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00033.2011"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2009.01900.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.3.690"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1212"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0278fje"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn.82.3.517"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2014.03.044"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.29986"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-44711"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2018.02.009"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2016.3047"}],"container-title":["Annals of Nutrition and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513287","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:13:11Z","timestamp":1745424791000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000513287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,3,31]]},"published-print":{"date-parts":[[2021,4,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000513287","archive":["Portico"],"relation":{},"ISSN":["0250-6807","1421-9697"],"issn-type":[{"type":"print","value":"0250-6807"},{"type":"electronic","value":"1421-9697"}],"subject":[],"published":{"date-parts":[[2020]]}}}