{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:26:53Z","timestamp":1745468813872,"version":"3.40.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Background:<\/i><\/b> The granulocyte-macrophage-colony-stimulating factor (GM-CSF) plays an important role in surfactant homeostasis. \u03b2<sub>C<\/sub> is a subunit of the GM-CSF receptor (GM-CSF-R), and its activation mediates surfactant catabolism in the lung. \u03b2<sub>IT<\/sub> is a physiological, truncated isoform of \u03b2<sub>C<\/sub> and is known to act as physiological inhibitor of \u03b2<sub>C<\/sub>. <b><i>Objective:<\/i><\/b> The aim of this study was to determine the ratio of \u03b2<sub>IT<\/sub> and \u03b2<sub>C<\/sub> in the peripheral blood of newborns and its association with the degree of respiratory failure at birth. <b><i>Methods:<\/i><\/b> We conducted a prospective cohort study in newborns with various degrees of respiratory impairment at birth. Respiratory status was assessed by a score ranging from no respiratory impairment (0) to invasive respiratory support (3). \u03b2<sub>IT<\/sub> and \u03b2<sub>C<\/sub> expression were determined in peripheral blood cells by real-time PCR. \u03b2<sub>IT<\/sub> expression, defined as the ratio of \u03b2<sub>IT<\/sub> and \u03b2<sub>C<\/sub>, was correlated with the respiratory score. <b><i>Results:<\/i><\/b> \u03b2<sub>IT<\/sub> expression was found in all 59 recruited newborns with a trend toward higher \u03b2<sub>IT<\/sub> in respiratory ill (score 2, 3) newborns than respiratory healthy newborns ([score 0, 1]; <i>p<\/i> = 0.066). Seriously ill newborns (score 3) had significantly higher \u03b2<sub>IT<\/sub> than healthy newborns ([score 0], <i>p<\/i> = 0.010). Healthy preterm infants had significantly higher \u03b2<sub>IT<\/sub> expression than healthy term infants (<i>p<\/i> = 0.019). <b><i>Conclusions:<\/i><\/b> \u03b2<sub>IT<\/sub> is expressed in newborns with higher expression in respiratory ill than respiratory healthy newborns. We hypothesize that \u03b2<sub>IT<\/sub> may have a protective effect in postnatal pulmonary adaptation acting as a physiological inhibitor of \u03b2<sub>C<\/sub> and, therefore, maintaining surfactant in respiratory ill newborns. <\/jats:p>","DOI":"10.1159\/000513356","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T21:01:18Z","timestamp":1617138078000},"page":"187-193","source":"Crossref","is-referenced-by-count":0,"title":["The Truncated Splice Variant of the Granulocyte-Macrophage-Colony-Stimulating Factor Receptor \u03b2- Chain in Peripheral Blood Serves as Severity Biomarker of Respiratory Failure in Newborns"],"prefix":"10.1159","volume":"118","author":[{"given":"Verena","family":"Schulte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Sipol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Burdach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Rieger-Fackeldey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,3,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022387"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1959.02070010519001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra023226"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM195806052582301"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1126\/science.8171324"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.12.5592"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.6.2657"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009750"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201708-1562OC"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1997.273.4.L715"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3109\/08977199309046929"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.2001.280.3.L379"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1989.tb08541.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-199805000-00005"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90039-2"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1084\/jem.183.4.1911"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-164004"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119758"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v91.1.54.54_54_63"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v98.9.2689"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-010-0201-9"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-009-0404-4"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-018-0891-z"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.2000.15b22.x"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513356","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:13:52Z","timestamp":1745424832000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000513356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,6,3]]},"published-print":{"date-parts":[[2021,6,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000513356","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2021]]}}}