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Karger AG","issue":"3","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; A combined regimen of rituximab with corticosteroids for the treatment of pemphigus was effective in a prospective randomized controlled trial. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To assess real-life response to rituximab in patients with pemphigus. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A retrospective cohort of patients with pemphigus treated with \u22651 rituximab cycles (1,000 mg on days 0 and 14). The primary outcome was remission rate after 1 cycle. For efficacy analyses, a minimal 6-month follow-up was required. Adverse events were assessed in all patients. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The cohort included 117 patients for safety analysis, 108 for efficacy analysis (median follow-up of 33 months). All but one received concomitant corticosteroids, a third also received adjuvants. Overall, 80\/108 patients (74%) achieved remission after the first rituximab cycle at a median of 5.5 months. Relapses occurred in 39 patients (49%) at a median of 18 months. Repeating treatment in relapsed patients increased remission rates to 75 and 88% after the second and third cycles, respectively. Adverse events were similar to those of previous publications. Two elderly patients died of infections attributable to rituximab combined with high-dose corticosteroids. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; In a large real-life long-term cohort, rituximab with corticosteroids \u00b1 adjuvants induced remission in most patients with pemphigus, with relatively favorable safety. Repeating treatment following relapse or remission failure was beneficial. <\/jats:p>","DOI":"10.1159\/000513515","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T22:03:21Z","timestamp":1612994601000},"page":"450-456","source":"Crossref","is-referenced-by-count":8,"title":["Treatment of Pemphigus with Rituximab: Real-Life Experience in a Cohort of 117 Patients in Israel"],"prefix":"10.1159","volume":"237","author":[{"given":"Adi","family":"Nosrati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmilia","family":"Hodak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomer","family":"Mimouni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9250-8351","authenticated-orcid":false,"given":"Meital","family":"Oren-Shabtai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4735-2890","authenticated-orcid":false,"given":"Assi","family":"Levi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yael\u00a0A.","family":"Leshem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Mimouni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,2,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90360-B"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114036"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60503-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1984.01650430127024"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70010-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005166"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.12.019"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.08.010"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.02.013"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067752"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30070-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.01.012"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.3236"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.6739"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.11.007"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.11.005"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.2808"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.03.020"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.5847.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06602.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04391.x"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513515","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:15:08Z","timestamp":1745424908000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000513515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,4,29]]},"published-print":{"date-parts":[[2021,5,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000513515","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.13850228","asserted-by":"subject"}]},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}