{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T10:25:48Z","timestamp":1788690348442,"version":"build-2803163510"},"reference-count":25,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background and Aims:&lt;\/i&gt;&lt;\/b&gt; Vitamin D deficiency has been associated with disease activity in Crohn\u2019s disease (CD). We assessed whether there is a correlation between vitamin D levels and the risk of postoperative recurrence in CD. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; CD patients who underwent surgery were identified from a\u202fprospectively maintained database at the University of Chicago. The primary endpoint was the correlation of serum 25-hydroxy vitamin D\u202flevels measured at 6\u201312 months after surgery and the proportion of patients in endoscopic remission, defined as a simple endoscopic score for CD of 0. Clinical, biological (C-reactive protein), and histologic recurrences were also studied. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Among a total of 89 patients, 17, 46, and 26 patients had vitamin D levels of &amp;#x3c;15, 15\u201330, and &amp;#x3e;30 ng\/mL, respectively. Patients with higher vitamin D levels were significantly more likely to be in endoscopic remission compared to those with lower levels (23, 42, and 67% in ascending tertile order; &lt;i&gt;p&lt;\/i&gt; = 0.028). On multivariate analysis, vitamin D &amp;#x3e;30 ng\/mL (odds ratio [OR] 0.22, 95% confidence interval [CI] 0.07\u20130.66, &lt;i&gt;p&lt;\/i&gt; = 0.006) and anti-tumor necrosis factor agent treatment (OR 0.25, 95% CI 0.08\u20130.83, &lt;i&gt;p&lt;\/i&gt; = 0.01) were associated with reduced risk of endoscopic recurrence. Rates of clinical, biological, and histologic remission trended to be higher in patients with higher vitamin D levels (&lt;i&gt;p&lt;\/i&gt; = 0.17, 0.55, 0.062, respectively). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; In the present study, higher vitamin D level was associated with lower risk of postoperative endoscopic CD recurrence. Further, studies are warranted to assess the role of vitamin D in postoperative CD recurrence. <\/jats:p>","DOI":"10.1159\/000513589","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T22:05:07Z","timestamp":1612821907000},"page":"767-775","source":"Crossref","is-referenced-by-count":12,"title":["The Correlation between Vitamin D Levels and the Risk of Postoperative Recurrence in Crohn\u2019s Disease"],"prefix":"10.1159","volume":"102","author":[{"given":"Akihiro","family":"Yamada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuga","family":"Komaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fukiko","family":"Komaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haider","family":"Haider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejan","family":"Micic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Pekow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushila","family":"Dalal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell D.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Cannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Umanskiy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhika","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D.","family":"Shogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Hurst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Hyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2519-6129","authenticated-orcid":false,"given":"Atsushi","family":"Sakuraba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,2,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.07.049"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.12.011"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2005.08.011"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1185\/030079905X65457"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90613-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90121-3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.10.051"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/470805"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i17.4934"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210\/me.2003-0281"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.11.2648"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C109.071225"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1072670"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2012.11.009"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izx054"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14951"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.06.023"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0b013e32833d4b9f"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3182250b3e"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1177\/0148607110381267"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e3182902ad9"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2014.45"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.07.041"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.4310\/SII.2011.v4.n1.a9"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513589","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513589","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:16:14Z","timestamp":1745424974000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000513589"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":25,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,9,1]]},"published-print":{"date-parts":[[2021,9,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000513589","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.13728790","asserted-by":"subject"}]},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}