{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T22:22:26Z","timestamp":1789942946371,"version":"4.0.1"},"reference-count":24,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Critically ill neonates are at high risk of kidney injury, mainly in the first days of life. Acute kidney injury (AKI) may be underdiagnosed due to lack of a uniform definition. In addition, long-term renal follow-up is limited. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To describe incidence, etiology, and outcome of neonates developing AKI within the first week after birth in a cohort of NICU-admitted neonates between 2008 and 2018. Renal function at discharge in infants with early AKI was assessed. &lt;b&gt;&lt;i&gt;Methods and Subjects:&lt;\/i&gt;&lt;\/b&gt; AKI was defined as an absolute serum Cr (sCr) value above 1.5 mg\/dL (132 \u03bcmol\/L) after the first 24 h or as stage 2\u20133 of the NIDDK neonatal definition. Clinical data and outcomes were collected from medical records and retrospectively analyzed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; From January 2008 to December 2018, a total of 9,376 infants were admitted to the NICU of Wilhelmina Children\u2019s Hospital\/UMC Utrecht, of whom 139 were diagnosed with AKI during the first week after birth. In 72 term infants, the most common etiology was perinatal asphyxia (72.2%), followed by congenital kidney and urinary tract malformations (CAKUT) (8.3%), congenital heart disease (6.9%), and sepsis (2.8%). Associated conditions in 67 preterm infants were medical treatment of a hemodynamic significant PDA (27.2%), \u00adCAKUT (21%), and birth asphyxia (19.4%). Among preterm neonates and neonates with perinatal asphyxia, AKI was mainly diagnosed by the sCr &amp;#x3e;1.5 mg\/dL criterion. Renal function at discharge improved in 76 neonates with AKI associated with acquired conditions. Neonates with stage 3 AKI showed increased sCr values at discharge. Half of these were caused by congenital kidney malformations and evolved into chronic kidney disease (CKD) later in life. Neurodevelopmental outcome (NDO) at 2 years was favorable in 93% of surviving neonates with detailed follow-up. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; During the first week after birth, AKI was seen in 1.5% of infants admitted to a level III NICU. Renal function at discharge had improved in most neonates with acquired AKI but not in infants diagnosed with stage 3 AKI. Long-term renal function needs further exploration, whereas NDO appears to be good. <\/jats:p>","DOI":"10.1159\/000513666","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T21:09:39Z","timestamp":1617052179000},"page":"174-179","source":"Crossref","is-referenced-by-count":39,"title":["Early Acute Kidney Injury in Preterm and Term Neonates: Incidence, Outcome, and Associated Clinical Features"],"prefix":"10.1159","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9532-2835","authenticated-orcid":false,"given":"Dario","family":"Gallo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen A.","family":"de Bijl-Marcus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Alderliesten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8956-0324","authenticated-orcid":false,"given":"Marc","family":"Lilien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-1637","authenticated-orcid":false,"given":"Floris","family":"Groenendaal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-3819"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s004670050068"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1081\/jdi-200026749"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-011-1977-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-012-0371-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2017\/23398.9327"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2017.136"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.10.048"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-010-1533-y"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmi017"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2015.217"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3582-y"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03670318"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/s0029-7844(02)01959-2"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-016-3317-5"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1701024"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3109\/15513815.2014.959678"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.1896"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000081797"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.230"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1177\/0883073815573319"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2162-4"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1463985"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.241"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513666","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513666","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:17:07Z","timestamp":1745425027000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000513666"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,6,3]]},"published-print":{"date-parts":[[2021,6,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000513666","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}