{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:06:33Z","timestamp":1787317593451,"version":"build-2736575974"},"reference-count":14,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Introduction:<\/i><\/b> There is a lack of evidence about the usefulness of exercise or rest in myasthenia gravis (MG). This study is aimed to evaluate the efficacy and safety of exercise or rest in MG. <b><i>Methods:<\/i><\/b> In a single-center open-labeled randomized controlled trial, the patients with mild to moderate MG were randomized to 30-min walk or rest in addition to the standard treatment. The primary endpoint was 50% improvement in the MG Quality of Life (MG-QOL15), and secondary endpoints were change in the Myasthenic Muscle Score (MMS), MG Activities of Daily Living (MGADL), grip strength, dose of acetylcholine esterase inhibitor and prednisone, 6-min walk test (6MWT), decrement in trapezius on the low-rate repetitive nerve stimulation test, and adverse events. The outcomes were defined at 3 months, by &#x3e;50% improvement in these outcome parameters. <b><i>Results:<\/i><\/b> Forty patients with MG were randomized to the exercise or rest arm. The 2 arms were matched for demographic and clinical parameters. The patients in the exercise arm had significantly better QOL evidenced by MG-QOL15 (<i>p =<\/i> 0.02). The secondary endpoints, distance covered in 6MWT (<i>p =<\/i> 0.007), were also better in the exercise arm without any adverse event. <b><i>Conclusion:<\/i><\/b> Regular exercise for 30 min in mild and moderate MG improves quality of life and walking distance compared to rest and is safe. <b><i>Clinical Trial Registration:<\/i><\/b> The clinical trial registration number is CTRI\/2019\/11\/021869.<\/jats:p>","DOI":"10.1159\/000513668","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T17:00:32Z","timestamp":1617987632000},"page":"168-174","source":"Crossref","is-referenced-by-count":15,"title":["Rest or 30-Min Walk as Exercise Intervention (RESTOREX) in Myasthenia Gravis: A Randomized Controlled Trial"],"prefix":"10.1159","volume":"84","author":[{"given":"Usha K.","family":"Misra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayantee","family":"Kalita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varun K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Kapoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhilasha","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhakar","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,4,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12193"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24696"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25552"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-017-2433-2"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26345"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-6884-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0b013e318225a26f"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1177\/1352458512437418"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25493"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.3.1524"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2007.01.001"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/808607"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201012-2079ED"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-019-1573-2"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513668","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513668","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:17:08Z","timestamp":1745410628000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000513668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,5,18]]},"published-print":{"date-parts":[[2021,5,25]]}},"URL":"https:\/\/doi.org\/10.1159\/000513668","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.14392970","asserted-by":"subject"}]},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}