{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T17:07:20Z","timestamp":1773248840843,"version":"3.50.1"},"reference-count":26,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Objective:<\/i><\/b> The aim of the study was to determine the influence of beta-adrenoceptor (ADRB) antagonists on contractile activity of the nonpregnant human uterus in patients affected by gynecological malignancies. <b><i>Design:<\/i><\/b> This was a controlled and prospective ex vivo study. <b><i>Setting:<\/i><\/b> The work was conducted as a collaboration between 4 academic departments. <b><i>Materials and Methods:<\/i><\/b> Myometrial specimens were obtained from women undergoing hysterectomy for benign gynecological disorders (reference group; <i>N<\/i> = 15), and ovarian (<i>N<\/i> = 15), endometrial (<i>N<\/i> = 15), synchronous ovarian-endometrial (<i>N<\/i> = 3), and cervical cancer (<i>N<\/i> = 10). Contractions of myometrial strips in an organ bath before and after applications of ADRB antagonists (propranolol, bupranolol, SR 59230A, and butoxamine) were studied under isometric conditions. <b><i>Results:<\/i><\/b> Propranolol and bupranolol attenuated contractions in the endometrial and cervical cancer groups similar to that in the reference group (all <i>p<\/i> &#x3c; 0.05), whereas opposite effects were observed in the ovarian and synchronous ovarian-endometrial cancer groups. SR 59230A and butoxamine significantly increased contractions in the ovarian cancer group (both <i>p<\/i> &#x3c; 0.001). <b><i>Limitations:<\/i><\/b> These results require now to be placed into a firm clinical context. <b><i>Conclusions:<\/i><\/b> Our study indicates that ovarian cancer considerably alters contractile activity of the nonpregnant human uterus in response to ADRB antagonists. This suggests a pathogenetic role of beta-adrenergic pathways in this malignancy. 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