{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:09:34Z","timestamp":1773281374054,"version":"3.50.1"},"reference-count":27,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Sleep-disordered breathing (SDB) in patients with motor neurone disease (MND) is normally attributed to hypoventilation due to muscle weakness. However, we have observed different patterns of SDB among MND patients referred for non-invasive ventilation, which do not appear to be explained by respiratory muscle weakness alone. &lt;b&gt;&lt;i&gt;Aim:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to examine the characteristics of SDB in MND. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This is a retrospective analysis of sleep studies (using polysomnography [PSG]), pulmonary function tests, and arterial blood gases in MND patients referred to a tertiary sleep medicine service for clinical review. Sleep apnoeas were characterised as obstructive or central, and to further characterise the nature of SDB, hypopnoeas were classified as obstructive versus central. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Among 13 MND patients who had a diagnostic PSG, the mean \u00b1 SD age was 68.9 \u00b1 9.8 years, BMI 23.0 \u00b1 4.3 kg\/m&lt;sup&gt;2&lt;\/sup&gt;, forced vital capacity 55.7 \u00b1 20.9% predicted, and partial pressure of CO&lt;sub&gt;2&lt;\/sub&gt; (arterial blood) 52.7 \u00b1 12.1 mm Hg. A total of 38% of patients (5\/13) showed evidence of sleep hypoventilation. The total apnoea\/hypopnoea index (AHI) was (median [interquartile range]) 44.4(36.2\u201356.4)\/h, with 92% (12\/13) showing an AHI &amp;#x3e;10\/h, predominantly due to obstructive events, although 8% (1\/13) also showed frequent central apnoea\/hypopnoeas. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Patients with MND exhibit a wide variety of SDB. The prevalence of obstructive sleep apnoea (OSA) is surprising considering the normal BMI in most patients. A dystonic tongue and increased upper-airway collapsibility might predispose these patients to OSA. The wide variety of SDB demonstrated might have implications for ventilator settings and patients\u2019 outcomes. <\/jats:p>","DOI":"10.1159\/000513887","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T21:07:21Z","timestamp":1617052041000},"page":"131-138","source":"Crossref","is-referenced-by-count":1,"title":["Sleep-Disordered Breathing in Patients with Motor Neurone Disease: One Size Does Not Fit all"],"prefix":"10.1159","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1149-7545","authenticated-orcid":false,"given":"Vinod","family":"Aiyappan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Catcheside","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick","family":"Antic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham","family":"Keighley-James","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Mercer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Doug","family":"McEvoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,3,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31287-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004427.pub4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70326-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-310055"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/CND.0000000000000234"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.12.19"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.4704"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-316515"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080\/14660820500504645"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080\/14660820510012031"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.3.9805008"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-510x(99)00044-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-510x(97)00241-4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1378\/chest.110.3.664"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/thx.49.2.157"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.19.5.637"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510x(94)90191-0"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.50.3.768"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.5665\/sleep.2450"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2015-312185"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq327"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2015-312606"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.3.9708056"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2005.052084"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2012.00095"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1590\/s1806-37132014000400013"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12269"}],"container-title":["Neurodegenerative Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513887","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513887","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:19:15Z","timestamp":1745425155000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000513887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,5,11]]},"published-print":{"date-parts":[[2021,5,18]]}},"URL":"https:\/\/doi.org\/10.1159\/000513887","archive":["Portico"],"relation":{},"ISSN":["1660-2854","1660-2862"],"issn-type":[{"value":"1660-2854","type":"print"},{"value":"1660-2862","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}