{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T14:19:41Z","timestamp":1781360381731,"version":"3.54.1"},"reference-count":22,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Background:<\/i><\/b> This study aimed to investigate the efficacy of enteral supplementation of vitamin B<sub>12<\/sub> for vitamin B<sub>12<\/sub> deficiency in patients who underwent total gastrectomy for gastric cancer. <b><i>Methods:<\/i><\/b> The study enrolled 133 patients who underwent total gastrectomy for gastric cancer at Kochi Medical School. Clinical data were obtained to investigate associations between vitamin B<sub>12<\/sub> supplementation and vitamin B<sub>12<\/sub> levels. Vitamin B<sub>12<\/sub> deficiency was defined as serum vitamin B<sub>12<\/sub> less than 200 pg\/mL. Baseline characteristics and changes in hematological variables, including vitamin B<sub>12<\/sub> levels, were examined. <b><i>Results:<\/i><\/b> Vitamin B<sub>12<\/sub> deficiency was present in 71.4% of the 133 patients. Vitamin B<sub>12<\/sub> levels at 3, 6, and 12 months after enteral supplementation were 306 pg\/mL, 294 pg\/mL, and 367 pg\/mL, respectively, which were all significantly higher than those before supplementation (<i>p<\/i> &#x3c; 0.001 for all comparisons). The median red blood cell count at 3, 6, and 12 months after enteral supplementation were 380 \u00d7 10<sup>4<\/sup>\/mm<sup>3<\/sup>, 394 \u00d7 10<sup>4<\/sup>\/mm<sup>3<\/sup>, and 395 \u00d7 10<sup>4<\/sup>\/mm<sup>3<\/sup>, respectively, which were all significantly higher than those before supplementation (<i>p<\/i> = 0.020, <i>p<\/i> = 0.001, and <i>p<\/i> = 0.003, respectively). Vitamin B<sub>12<\/sub> levels at 3, 6, and 12 months after supplementation were significantly higher in patients supplemented enterally than those supplemented parenterally (<i>p<\/i> &#x3c; 0.001 for all comparisons). <b><i>Conclusions:<\/i><\/b> Vitamin B<sub>12<\/sub> deficiency was found in 71.4% of postoperative patients who underwent total gastrectomy for gastric cancer, and enteral vitamin B<sub>12<\/sub> supplements might be effective to improve anemia in these patients. <\/jats:p>","DOI":"10.1159\/000513888","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T08:06:03Z","timestamp":1613808363000},"page":"225-233","source":"Crossref","is-referenced-by-count":11,"title":["Enteral Vitamin B<sub>12<\/sub> Supplementation Is Effective for Improving Anemia in Patients Who Underwent Total Gastrectomy"],"prefix":"10.1159","volume":"99","author":[{"given":"Tsutomu","family":"Namikawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichiro","family":"Yokota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Iwabu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaya","family":"Munekage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunao","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromichi","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiya","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Hanazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i26.2818"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30677-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i42.6114"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.5908"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2016.02.084"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.4644"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-1764-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200008000-00008"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-011-0042-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-011-0040-6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/0884533608314536"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa072252"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqy072"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000481860"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2018.02.037"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000214"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v92.4.1191"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-011-0777-8"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2498-4"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2018.08.014"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-016-1341-5"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.165.10.1167"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513888","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/513888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:19:16Z","timestamp":1745425156000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000513888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":22,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,3,31]]},"published-print":{"date-parts":[[2021,4,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000513888","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}