{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:47:11Z","timestamp":1760986031141,"version":"3.40.5"},"reference-count":14,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T00:00:00Z","timestamp":1614729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Oncol"],"abstract":"<jats:p>Intimal sarcoma arising from the tunica intima of both systemic and pulmonary circulations is a rare disorder, whereas intimal sarcoma with chondroblastic osteosarcomatous differentiation (ISCOS) is even rarer. We present the case of a 25-year-old woman with ISCOS of the pulmonary artery (PA) where the patient went through surgical treatment after careful imaging assessment under a rather emergent situation. A 25-year-old Japanese female presented to our hospital with the chief complaints of dyspnea and palpitations on exertion. Upon arrival, she had systolic murmur, moderate tricuspid regurgitation, and possible pulmonary hypertension. A contrast-enhanced chest computed tomography (CT) showed dilatation of the main PA, filled with a hypodense area with calcification adjacent to the right and left PA. The calcified lesions within the tumor were the key findings suggesting osteoid-forming sarcoma, differentiating it from pulmonary embolism. Due to presence of critical symptomatic obliteration of the pulmonary circulation, an emergency surgery was performed. A whitish shiny mass filled the lumens from the main PA to the bilateral main PAs. The tumor was not attached to the surrounding intima, except for a slight attachment to the left interlobar PA, and could be completely removed from the vessel lumen. Based on the pathological findings, it was diagnosed as a primary ISCOS of the PA, which correlated with the findings of the CT, namely intratumoral calcification. Although the diagnosis-making is quite challenging, multidisciplinary collaboration between clinicians, radiologists, and pathologists is crucial for reaching the correct diagnosis. <\/jats:p>","DOI":"10.1159\/000514051","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T16:51:48Z","timestamp":1616518308000},"page":"318-324","source":"Crossref","is-referenced-by-count":3,"title":["Primary Intimal Sarcoma of the Pulmonary Artery in a 25-Year-Old Woman with Dyspnea and Palpitation: A Case Report"],"prefix":"10.1159","volume":"14","author":[{"given":"Hiroko","family":"Onagi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8935-0768","authenticated-orcid":false,"given":"Yoshiya","family":"Horimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Arai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Terukina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7069-2805","authenticated-orcid":false,"given":"Tohru","family":"Asai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,3,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930301)71:5%3c1761::aid-cncr2820710510%3e3.0.co;2-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318180720d"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0000000000000182"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000476036"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.11.098"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-008-0671-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.5114\/jcb.2019.91226"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-4975(03)00761-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31817d7fd0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2018.19.4.792"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-015-3449-y"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1148\/rg.291085061"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-7-154"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezu184"}],"container-title":["Case Reports in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514051","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:20:45Z","timestamp":1745425245000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000514051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,3]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,5,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000514051","archive":["Portico"],"relation":{},"ISSN":["1662-6575"],"issn-type":[{"type":"electronic","value":"1662-6575"}],"subject":[],"published":{"date-parts":[[2021,3,3]]}}}