{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T11:30:58Z","timestamp":1774611058707,"version":"3.50.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"5-6","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Introduction:<\/i><\/b> Numerous factors such as endothelial disease and hormonal disorder cause the development of erectile dysfunction (ED). However, the relationship between vitamin D deficiency (VDD) and ED is unclear. Moreover, the benefit of vitamin D replacement on ED patients with VDD is uncertain. As far as we know, there is no study yet in the literature regarding the addition of vitamin D to phosphodiesterase type 5 inhibitors in the treatment of ED patients with VDD. In this study, we investigated whether adding vitamin D to daily tadalafil treatment would be beneficial in ED patients with VDD. <b><i>Methods:<\/i><\/b> A total of 111 patients with VDD accompanying ED were retrospectively evaluated between January 2016 and December 2019. Patients were divided into 2 groups according to the treatment they received. Group 1 (<i>n<\/i> = 58) was treated with daily oral tadalafil 5 mg, while group 2 (<i>n<\/i> = 53) received oral tadalafil 5 mg and 4,000 IU vitamin D3. Total International Index of Erectile Function-15 (IIEF-15) scores and vitamin D levels of the groups were compared at the end of the study. <b><i>Results:<\/i><\/b> The mean vitamin D level was increased statistically significant in group 2, but no difference was seen in group 1 (<i>p<\/i> &#x3c; 0.001 and <i>p<\/i> &#x3e; 0.05, respectively). There was a significant increase in median erectile function, orgasmic function, sexual desire, sexual satisfaction, and overall satisfaction scores in both groups (<i>p<\/i> &#x3c; 0.001). However, the increase in median erectile function and sexual desire scores was significantly higher in group 2 compared to group 1 at the end of the study (<i>p<\/i> = 0.01 and <i>p<\/i> &#x3c; 0.001, respectively). <b><i>Conclusion:<\/i><\/b> We found that adding vitamin D to 5 mg oral daily tadalafil treatment may have an additional positive effect on erectile function and sexual desire in ED patients with VDD. <\/jats:p>","DOI":"10.1159\/000514056","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T21:00:41Z","timestamp":1617224441000},"page":"514-519","source":"Crossref","is-referenced-by-count":11,"title":["Whether Adding Vitamin D to Tadalafil 5 mg Treatment Is Useful in Patients with Erectile Dysfunction and Vitamin D Deficiency?"],"prefix":"10.1159","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8921-4571","authenticated-orcid":false,"given":"Aykut","family":"Demirci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"\u00c7akan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Top\u00e7uo\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,3,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(17)34871-1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2011.05.2279"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI15219"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/me.2013-1252"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2103"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141770"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6030646"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000330075"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04672.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.190151"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/and.13211"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3720813"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200363200-00004"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/s41443-018-0036-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.5152\/tud.2017.76032"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080\/13685538.2016.1271783"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s42000-018-0059-8"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2704"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/nu12020575"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514056","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:20:47Z","timestamp":1745425247000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000514056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":20,"journal-issue":{"issue":"5-6","published-online":{"date-parts":[[2021,4,30]]},"published-print":{"date-parts":[[2021,5,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000514056","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}