{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:23:36Z","timestamp":1789043016954,"version":"build-2803163510"},"reference-count":34,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; Data regarding the potential association between the outcome of psychotherapy of panic disorder (PD) and biological parameters are few. In 21 (16 females) consecutively referred, medication-free, acutely ill PD outpatients, without comorbidities, except agoraphobia, we systematically explored for potential neuroendocrine and clinical correlates of response to a brief cognitive behavior therapy (CBT). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Cortisol and adrenocorticotropic hormone (ACTH) basal plasma levels were measured. Measures of psychopathology: (a) Symptom Checklist\u201390-Revised (SCL-90-R), (b) Clinical Global Impressions-Improvement (CGI-I) Scale, (c) Agoraphobic Cognitions Questionnaire (ACQ), and (d) Mobility Inventory (MI)-alone subscale. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Nonresponders to CBT (CGI-I &amp;#x3e;2; &lt;i&gt;N&lt;\/i&gt; = 6) \u2013 as compared to the responders (CGI-I \u22642; &lt;i&gt;N&lt;\/i&gt; = 15) \u2013 demonstrated significantly &lt;i&gt;higher&lt;\/i&gt; cortisol and ACTH basal plasma concentrations. These differences were much stronger when only female patients (nonresponders = 4; responders = 12) were taken into consideration. Regarding psychopathology, nonresponders to CBT suffered from more severe agoraphobia (MI-alone) at baseline. On the contrary, more intense manifestations of anger (SCL-90-R) at baseline were associated with a better treatment outcome. Response to CBT was associated with significant reductions in all SCL-90-R subscales, more pronounced for \u201cphobic anxiety\u201d and \u201canxiety\u201d subscales. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; This study suggests that in acutely ill, medication-free PD patients, response to CBT may be associated with certain hormonal and clinical parameters at baseline. <\/jats:p>","DOI":"10.1159\/000514073","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T21:07:39Z","timestamp":1617052059000},"page":"401-410","source":"Crossref","is-referenced-by-count":5,"title":["Stress Hormones as Predictors of Response to Cognitive Behavior Therapy in Panic Disorder"],"prefix":"10.1159","volume":"80","author":[{"given":"Vasilios G.","family":"Masdrakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia-Maria","family":"Legaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charalambos","family":"Papageorgiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manolis","family":"Markianos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,3,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4530(94)e0022-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2013.01.002"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2017.05.025"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.30773\/pi.2018.07.26"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2018.11.017"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2010.07.002"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1017\/S135246581300101X"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2015.09.004"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2016.11.030"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-017-0081-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1993.01820160076009"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.4.493"},{"key":"ref13"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/da.20220"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2015.07.069"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.143.7.896"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90035-8"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(95)00035-6"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(88)90201-6"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.10.008"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2016.09.008"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/NMD.0000000000000419"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.1.56"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1037\/\/0022-006x.52.6.1090"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(85)90140-8"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1002\/da.21910"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199801153380307"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1080\/16506070410031691"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291707000670"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2008.01799.x"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2003.09.002"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1002\/da.20223"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1002\/da.20280"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.08.023"}],"container-title":["Neuropsychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514073","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:20:54Z","timestamp":1745425254000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000514073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":34,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,10,5]]},"published-print":{"date-parts":[[2021,12,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000514073","archive":["Portico"],"relation":{},"ISSN":["0302-282X","1423-0224"],"issn-type":[{"value":"0302-282X","type":"print"},{"value":"1423-0224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}