{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:28:52Z","timestamp":1761920932442,"version":"3.40.4"},"reference-count":25,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T00:00:00Z","timestamp":1634256000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Background:<\/i><\/b> Genetic factors were suggested to have influence on the development of post-traumatic stress disorder (PTSD). The possible association between catechol-O-methyltransferase (<i>COMT<\/i>) Val158Met polymorphism and PTSD has been evaluated in several studies. But the results were still controversial. Therefore, we conduct this meta-analysis to address these issues. <b><i>Methods:<\/i><\/b> The PubMed, EMBASE, Cochrane Library, and Web of Science databases were searched for eligible studies. The pooled odds ratio (OR) with 95% confidence interval (CI) was calculated to estimate the association between <i>COMT<\/i> Val158Met polymorphism and PTSD. <b><i>Results:<\/i><\/b> Five articles including 6 studies with 893 cases and 968 controls were finally included in the present meta-analysis. The pooled analyses did not demonstrate a significant association between the <i>COMT<\/i> Val158Met polymorphism and PTSD in any of the selected genetic models: allele model (OR = 1.13, 95% CI: 0.97\u20131.31), dominant model (OR = 1.17, 95% CI: 0.93\u20131.46), recessive model (OR = 1.44, 95% CI: 0.78\u20132.66), and additive model (OR = 1.54, 95% CI: 0.85\u20132.80). Subgroup analyses suggested that the Hardy-Weinberg equilibrium status of genotype distributions could influence the relationship of <i>COMT<\/i> Val158Met polymorphism and PTSD. <b><i>Conclusions:<\/i><\/b> The present meta-analysis suggested that the <i>COMT<\/i> Val158Met polymorphism may not be associated with the PTSD risk. Further large-scale and population-representative studies are warranted to evaluate the impact of the <i>COMT<\/i> Val158Met polymorphism on the risk of PTSD. <\/jats:p>","DOI":"10.1159\/000514076","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T21:00:33Z","timestamp":1634331633000},"page":"156-170","source":"Crossref","is-referenced-by-count":3,"title":["The Association between <b><i>COMT<\/i><\/b> Val158Met Polymorphism and the Post-Traumatic Stress Disorder Risk: A Meta-Analysis"],"prefix":"10.1159","volume":"81","author":[{"given":"Mi","family":"Su","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongyan","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,10,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1177\/070674370204701003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.593"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717000708"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1375\/136905203765693870"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2009.10.002"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/s0376-8716(00)00127-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-007-0787-2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.08m04787blu"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2004.05.011"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1086\/425589"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.01.012"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-9280.2009.02280.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.10.009"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2009.36"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1089\/cap.2014.0077"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.12.033"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.24869\/psyd.2019.241"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066227"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-009-0260-7"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2012.06.026"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.10.017"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2011.01.010"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2013.09.012"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1521\/psyc.2013.76.3.256"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2012.180"}],"container-title":["Neuropsychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514076","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:20:56Z","timestamp":1745425256000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000514076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,15]]},"references-count":25,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,4,1]]},"published-print":{"date-parts":[[2022,4,5]]}},"URL":"https:\/\/doi.org\/10.1159\/000514076","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.16817398","asserted-by":"subject"}]},"ISSN":["0302-282X","1423-0224"],"issn-type":[{"type":"print","value":"0302-282X"},{"type":"electronic","value":"1423-0224"}],"subject":[],"published":{"date-parts":[[2021,10,15]]}}}