{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:47:29Z","timestamp":1790390849104,"version":"4.1.0"},"reference-count":27,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T00:00:00Z","timestamp":1618963200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Blood Purif"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Purpose:<\/i><\/b> Recent research has shown that hypomagnesemia is associated with increased all-cause mortality in hemodialysis patients. However, the relationship between the long-term prognosis of peritoneal dialysis (PD) and the study is not yet clear. This study will analyze the effects of hypomagnesemia on all-cause, cardiovascular diseases (CVD), and non-CVD mortality in PD patients. <b><i>Method:<\/i><\/b> In a retrospective cohort study, 1,004 samples were selected from 7 PD centers in China. Based on the baseline blood magnesium level at the beginning of stable dialysis, all patients were classified into blood magnesium &#x3c;0.7 mmol\/L group, 0.7\u20131.2 mmol\/L group, and &#x3e;1.2 mmol\/L group (the end event was death). The Kaplan-Meier method was used to calculate the difference in cumulative survival rate; the Cox proportional hazard model was used to analyze the risk factors of all-cause, CVD, and non-CVD death causes. <b><i>Results:<\/i><\/b> Cox multiple regression analysis results (reference comparison of 0.7\u20131.2 mmol\/L group): patients with serum magnesium &#x3c;0.7 mmol\/L have a higher risk ratio of all-cause mortality (HR = 1.580, 95% CI: 1.222\u20132.042, <i>p<\/i> = 0.001), and it is also obvious after correction by multiple models (HR = 1.578, 95% CI: 1.196\u20132.083, <i>p<\/i> = 0.001). Subgroup analysis of the causes of death was as follows: CVD risk (HR = 1.628, 95% CI: 1.114\u20132.379, <i>p<\/i> = 0.012) and non-CVD risk (HR = 1.521, 95% CI: 1.011\u20132.288, <i>p<\/i> = 0.044). Further analysis of the causes of infection-related death in non-CVD is also significant (HR = 1.919, 95% CI: 1.131\u20133.1257, <i>p<\/i> = 0.016). On the other hand, the serum magnesium&#x3e;1.2 mmol\/L group had lower all-cause mortality after correction (HR = 0.687, 95% CI: 0.480\u20130.985, <i>p<\/i> = 0.041), and subgroup analysis of the cause of death had no statistical significance (<i>p<\/i> &#x3e; 0.05). <b><i>Conclusions:<\/i><\/b> Hypomagnesemia (serum magnesium &#x3c;0.7 mmol\/L) during stable dialysis in PD patients is a risk factor for CVD- and non-CVD-related mortality, especially infection-related death causes. <\/jats:p>","DOI":"10.1159\/000514148","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T21:03:28Z","timestamp":1619039008000},"page":"23-30","source":"Crossref","is-referenced-by-count":14,"title":["Hypomagnesemia Is a Risk Factor for Cardiovascular Disease- and Noncardiovascular Disease-Related Mortality in Peritoneal Dialysis Patients"],"prefix":"10.1159","volume":"51","author":[{"given":"Fengping","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianfeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqiang","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojiang","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen 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