{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T17:14:19Z","timestamp":1780938859335,"version":"3.54.1"},"reference-count":28,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Addict Res"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Background:<\/i><\/b> Research on quality of life (QoL) of chronically ill patients provides an opportunity to evaluate the efficacy of long-term treatments. Although it is established that opioid replacement therapy is an effective treatment for opioid-dependent patients, there is little knowledge about physical and psychological functioning of QoL for different treatment options. <b><i>Objectives:<\/i><\/b> Altogether, 248 opioid-dependent patients receiving substitution treatment with either methadone\/levomethadone (<i>n<\/i> = 126), diamorphine (<i>n<\/i> = 85), or buprenorphine (<i>n<\/i> = 37) were recruited in 6 German therapy centers. <b><i>Methods:<\/i><\/b> Sociodemographic data were collected. QoL \u2013 physical and psychological functioning \u2013 for different substitutes was assessed using the <i>Profile of the Quality of Life in the Chronically Ill<\/i> (PLC) questionnaire. <b><i>Results:<\/i><\/b> Patient groups were similar regarding age and duration of opioid dependence. Employment rate was significantly higher (<i>p<\/i> &#x3c; 0.005, \u03c6 = 0.22) in the buprenorphine group (46%) compared to methadone (18%). Dosage adjustments were more frequent (<i>p<\/i> &#x3c; 0.001, \u03c6 = 0.29) in diamorphine (55%) than in methadone (30%) or buprenorphine (19%) patients. Buprenorphine and diamorphine patients rated their physical functioning substantially higher than methadone patients (<i>p<\/i> &#x3c; 0.001, \u03b7<sup>2<\/sup> = 0.141). Diamorphine patients reported a higher psychological functioning (<i>p<\/i> &#x3c; 0.001, \u03b7<sup>2<\/sup> = 0.078) and overall life improvement (<i>p<\/i> &#x3c; 0.001, \u03b7<sup>2<\/sup> = 0.060) compared to methadone, but not compared to buprenorphine patients (both <i>p<\/i> &#x3e; 0.25). <b><i>Conclusion:<\/i><\/b> Measurement of important QoL aspects indicates significant differences for physical and psychological functioning in patients receiving the substitutes methadone\/levomethadone, diamorphine, and buprenorphine. This could be relevant for the differential therapy of opioid addiction. <\/jats:p>","DOI":"10.1159\/000514192","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T21:01:18Z","timestamp":1617138078000},"page":"371-380","source":"Crossref","is-referenced-by-count":11,"title":["Quality of Life in Opioid Replacement Therapy: A Naturalistic Cross-Sectional Comparison of Methadone\/Levomethadone, Buprenorphine, and Diamorphine Patients"],"prefix":"10.1159","volume":"27","author":[{"given":"Stephanie Paula Elisabeth","family":"Guillery","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Hellweg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Golo","family":"Kronenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Bohr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagen","family":"Kunte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f6ren","family":"Enge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,3,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-32713"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2017.10.008"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16071299"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1032322"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1024\/2007.05.05"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1024\/2007.05.03"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-812915"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2019.05.003"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.4103\/jehp.jehp_297_13"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080\/00952990701523698"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.2.340"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080\/09652140020039053"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000496112"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000505207"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-017-1674-6"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2015.1014948"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-926778"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1080\/09595230801935706"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000274177"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s11469-020-00313-0"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1177\/0269881106060835"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13818"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6904-7-5"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159\/000052034"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.1999.94913376.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13m08725"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.046433"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1559-1816.2000.tb02462.x"}],"container-title":["European Addiction Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514192","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:22:09Z","timestamp":1745425329000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000514192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":28,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,8,12]]},"published-print":{"date-parts":[[2021,8,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000514192","archive":["Portico"],"relation":{},"ISSN":["1022-6877","1421-9891"],"issn-type":[{"value":"1022-6877","type":"print"},{"value":"1421-9891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}