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Karger AG","issue":"3","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>We report perhaps the most comprehensive study of subsets of CD4+ and CD8+ and subsets of B cells in a mild symptomatic SARS-CoV-2+ immunocompetent patient and a common variable immunodeficiency disease (CVID) patient who had normal absolute lymphocyte counts and remained negative for SARS-CoV-2 IgG antibodies. Na\u00efve (T&lt;sub&gt;N&lt;\/sub&gt;), central memory (T&lt;sub&gt;CM&lt;\/sub&gt;), effector memory (T&lt;sub&gt;EM&lt;\/sub&gt;), and terminally differentiated effector memory (T&lt;sub&gt;EMRA&lt;\/sub&gt;) subsets of CD4+ and CD8+ T cells, subsets of T follicular helper cells (cT&lt;sub&gt;FH&lt;\/sub&gt;, T&lt;sub&gt;FH&lt;\/sub&gt;1, T&lt;sub&gt;FH&lt;\/sub&gt;2, T&lt;sub&gt;FH&lt;\/sub&gt;17, T&lt;sub&gt;FH&lt;\/sub&gt;1\/T&lt;sub&gt;FH&lt;\/sub&gt;17, and T&lt;sub&gt;FR&lt;\/sub&gt;), CD4 Treg, CD8 Treg, mature B cells, transitional B cells, marginal zone B cells, germinal center (GC) B cells, CD21&lt;sup&gt;low&lt;\/sup&gt; B cells, antibody-secreting cells (plasmablasts), and Breg cells were examined in patients and age-matched controls with appropriate monoclonal antibodies and isotype controls using multicolor flow cytometry. Different patterns of abnormalities (often contrasting) were observed in the subsets of CD4+ T, CD8+ T, B-cell subsets, and regulatory lymphocytes among the immunocompetent patient and CVID patient as compared to corresponding healthy controls. Furthermore, when data were analyzed between the 2 patients, the immunocompetent patient demonstrated greater changes in various subsets as compared to the CVID patient. These data demonstrate different immunological responses to SARS-CoV-2 infection in an immunocompetent patient and the CVID patient. A marked decrease in GC B cells and plasmablasts may be responsible for failure to make SARS-CoV-2 antibodies. The lack of SARS-CoV-2 antibodies with mild clinical disease suggests an important role of T-cell response in defense against SARS-CoV-2 infection. <\/jats:p>","DOI":"10.1159\/000514193","type":"journal-article","created":{"date-parts":[[2021,1,22]],"date-time":"2021-01-22T22:01:36Z","timestamp":1611352896000},"page":"195-209","source":"Crossref","is-referenced-by-count":42,"title":["SARS-CoV-2-Associated T-Cell Responses in the Presence of Humoral 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