{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T23:50:08Z","timestamp":1774396208785,"version":"3.50.1"},"reference-count":13,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>SARS-CoV-2 has been reported as a possible triggering factor for the development of several autoimmune diseases and inflammatory dysregulation. Here, we present a case report of a woman with a history of systemic lupus erythematosus and antiphospholipid syndrome, presenting with concurrent COVID-19 infection and immune thrombotic thrombocytopenic purpura (TTP). The patient was treated with plasma exchange, steroids, and caplacizumab with initial good response to therapy. The course of both TTP and COVID-19 disease was mild. However, after ADAMTS-13 activity was normalized, the patient experienced an early unexpected TTP relapse manifested by intravascular hemolysis with stable platelet counts requiring further treatment. Only 3 cases of COVID-19 associated TTP were reported in the literature thus far. We summarize the literature and suggest that COVID-19 could act as a trigger for TTP, with good outcomes if recognized and treated early. <\/jats:p>","DOI":"10.1159\/000514283","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T21:04:34Z","timestamp":1619211874000},"page":"678-682","source":"Crossref","is-referenced-by-count":13,"title":["An Early Unexpected Immune Thrombotic Thrombocytopenic Purpura Relapse Associated with SARS-CoV-2 Infection: A Case Report and Literature Review"],"prefix":"10.1159","volume":"144","author":[{"given":"Maya","family":"Kornowski Cohen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liron","family":"Sheena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yair","family":"Shafir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5043-8690","authenticated-orcid":false,"given":"Vered","family":"Yahalom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anat","family":"Gafter-Gvili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galia","family":"Spectre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,4,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-020-04097-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-925469"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2014-000078"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07107.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(20)30216-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-020-02394-0"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.05.032"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.613"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000109253.66918.5E"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806311"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2019.11.022"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-10-833988"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2016.1.446"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514283","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:23:10Z","timestamp":1745425390000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000514283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":13,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,11,22]]},"published-print":{"date-parts":[[2021,11,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000514283","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.14472708","asserted-by":"subject"}]},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}