{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:52:15Z","timestamp":1787017935475,"version":"build-2736575974"},"reference-count":28,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intervirology"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Objectives:<\/i><\/b> The aim of present work was to assess cytomegalovirus (CMV) viremia in Iranian human immunodeficiency virus (HIV)-1-infected patients with a CD4+ count &#x3c;100 cells\/mm<sup>3<\/sup> and to explore whether CMV DNA loads correlate with CD4+ cell counts or associated retinitis. <b><i>Methods:<\/i><\/b> This study was conducted at the AIDS research center in Iran on HIV-1-infected patients with CD4+ count &#x3c;100 cells\/mm<sup>3<\/sup>, antiretroviral therapy-naive, aged \u226518 years with no previous history of CMV end-organ disease (CMV-EOD). <b><i>Results:<\/i><\/b> Thirty-nine of 82 patients (47.56%) had detectable CMV viral load ranging from 66 to 485,500 IU\/mL. CMV viral load in patients with retinitis ranges from 352 to 2,720 IU\/mL, and it was undetectable in 2 patients. No significant associations between CMV viremia and CD4+ cell count was found (<i>p<\/i> value = 0.31), whereas significant association of CMV viremia in HIV-infected patients with retinitis was found (<i>p<\/i> &#x3c; 0.02). <b><i>Conclusions:<\/i><\/b> We estimated the frequency of CMV viral load infection in Iranian HIV-1-infected patients with a CD4+ cell count &#x3c;100 mm<sup>3<\/sup>\/mL in the largest national referral center for HIV-1 infection in Iran. Further research is required on the relevance of CMV viral load in diagnostic and prognostic value of CMV-EOD.<\/jats:p>","DOI":"10.1159\/000514385","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T17:00:41Z","timestamp":1617210041000},"page":"135-139","source":"Crossref","is-referenced-by-count":5,"title":["Frequency of Cytomegalovirus Viral Load in Iranian Human Immunodeficiency Virus-1-Infected Patients with CD4+ Counts &#x3c;100 Cells\/mm<sup>3<\/sup>"],"prefix":"10.1159","volume":"64","author":[{"given":"Mohammad Reza","family":"Jabbari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1931-7801","authenticated-orcid":false,"given":"Hoorieh","family":"Soleimanjahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Shatizadeh Malekshahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Gholami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoo","family":"Mohraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,3,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093702"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2727.176228"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160493"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit173"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-005-5050-z"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2006.03.005"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10349"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit494"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2010.02712.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.186965"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4103\/njcp.njcp_82_18"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofz439"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-326"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2012.27.5.542"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2007.07.002"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2652-14-41"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-312191"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2010.02400.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1080\/09286580802077716"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025571"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/171.1.177"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1101"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00136"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2010.00900.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/01.qai.0000155204.96973.c3"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/s0163-4453(99)90047-6"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.10.3124-3132.1999"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1086\/323782"}],"container-title":["Intervirology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514385","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:24:00Z","timestamp":1745411040000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000514385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,7,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000514385","archive":["Portico"],"relation":{},"ISSN":["0300-5526","1423-0100"],"issn-type":[{"value":"0300-5526","type":"print"},{"value":"1423-0100","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}