{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T03:32:41Z","timestamp":1770780761146,"version":"3.50.0"},"reference-count":13,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Acetylsalicylic acid hypersensitivity (ASAH) limits therapeutic options in patients with acute coronary syndrome (ACS), who benefit from dual antiplatelet therapy (DAPT), especially when undergoing stent implantation. Our aim was to evaluate the safety and efficacy of triflusal in patients with ACS and ASAH. &lt;b&gt;&lt;i&gt;Methods and Results:&lt;\/i&gt;&lt;\/b&gt; Two-center retrospective study of patients diagnosed with ACS and ASAH from January 1, 2000, to May 1, 2020. Sixty-six patients were treated with triflusal. ASAH was confirmed with tests in 15 patients (22.7%). Forty-nine patients (74.2%) presented history of other drug allergies. Fifty-nine patients (89.4%) underwent stent implantation. DAPT was prescribed for \u226512 months in 54 patients. No adverse reactions to triflusal were reported. During a median follow-up of 5.12 years [IQR 2.7\u20139.9], rate of cardiovascular (CV) mortality was 6.1%, nonfatal myocardial infarction 12.1%, and ischemic stroke 4.5%. No cases of definite stent thrombosis occurred. Bleeding Academic Research Consortium grade \u22652 was observed in 3 patients during follow-up. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; In this series of patients presenting with ACS and ASA hypersensitivity, triflusal showed good tolerability and was associated with a low rate of CV and bleeding events. <\/jats:p>","DOI":"10.1159\/000514414","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T06:24:10Z","timestamp":1624861450000},"page":"426-430","source":"Crossref","is-referenced-by-count":3,"title":["Triflusal in Patients with Acute Coronary Syndrome and Acetylsalicylic Acid Hypersensitivity"],"prefix":"10.1159","volume":"146","author":[{"given":"Georgina","family":"Fuertes Ferre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ainhoa","family":"P\u00e9rez Guerrero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Antonio","family":"Linares Vicente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Jimeno S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanesa","family":"Alonso-Ventura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Luis","family":"Cubero Salda\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Gabriel","family":"Galache Osuna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva Mar\u00eda","family":"Andr\u00e9s Esteban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Antonio","family":"Diarte de Miguel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria del Rosario","family":"Ortas Nadal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Antonio","family":"Casasnovas Lenguas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.116.004368"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2019.03.047"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.23736\/S0026-4725.19.04787-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2018.06.011"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3466.2006.00011.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01473.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2174\/1570161116666180605090520"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.1999.1874"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2017.85"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.08.080"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s40256-019-00373-1"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2017.05.007"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514414","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:24:10Z","timestamp":1745425450000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000514414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,7,20]]},"published-print":{"date-parts":[[2021,9,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000514414","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.14267540","asserted-by":"subject"}]},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}