{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T10:35:07Z","timestamp":1778927707519,"version":"3.51.4"},"reference-count":38,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Complement Med Res"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Evidence favoring homeopathy in generalized anxiety disorder (GAD) remains scarce. The objective of this pilot trial was to test feasibility of a definitive trial in future. We also experimented whether individualized homeopathic medicines (IH) plus psychological counseling (PC) can produce significantly different effects beyond placebo plus PC in the treatment of GAD. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A double-blind, randomized, placebo-controlled, parallel arm, pilot trial was conducted on 62 GAD patients at the National Institute of Homoeopathy, India. GAD-7 questionnaire and Hamilton Anxiety Scale (HAM-A) were used as the primary and secondary outcomes, respectively, measured at baseline and 3 months. Patients received either IH plus PC (&lt;i&gt;n&lt;\/i&gt; = 31) or identical-looking placebo plus PC (&lt;i&gt;n&lt;\/i&gt; = 31). Intention-to-treat sample was analyzed to detect group differences using unpaired &lt;i&gt;t&lt;\/i&gt; tests. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Recruitment and retention rates were 56 and 90%, respectively. Mean age was 31.5 years; 56.5% were male. GAD-7 reductions were non-significantly higher in IH than placebo (&lt;i&gt;p&lt;\/i&gt; = 0.122). Group differences on HAM-A favored IH significantly (&lt;i&gt;p&lt;\/i&gt; = 0.018). Effect sizes were small to medium. &lt;i&gt;Calcarea carbonica&lt;\/i&gt; was the most frequently indicated medicine. No serious adverse events happened. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; A small but positive direction of anxiolytic effect was observed favoring homeopathy over placebo. A definitive trial appeared feasible in future. <\/jats:p>","DOI":"10.1159\/000514524","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T21:08:36Z","timestamp":1617052116000},"page":"407-418","source":"Crossref","is-referenced-by-count":8,"title":["Individualized Homeopathic Medicines in the Treatment of Generalized Anxiety Disorder: A Double-Blind, Randomized, Placebo-Controlled, Pilot Trial"],"prefix":"10.1159","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3592-0953","authenticated-orcid":false,"given":"Maneet","family":"Parewa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avijit\u00a0Shee","family":"Burman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arabinda","family":"Brahma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1139-6285","authenticated-orcid":false,"given":"Lex","family":"Rutten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satarupa","family":"Sadhukhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankhuri","family":"Misra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharti","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitin","family":"Saklani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Michael","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anamika","family":"Basu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sk.\u00a0Swaif","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munmun","family":"Koley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2308-5265","authenticated-orcid":false,"given":"Subhranil","family":"Saha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,3,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/da.20257"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2011.07.018"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordhb\/9780195307030.013.0002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1017\/S003329171200147X"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5545.71009"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1017\/S1121189X00001421"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.5.669"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000073451"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-146-5-200703060-00004"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.homp.2006.05.005"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4088\/jcp.v64n0309"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2005.11.13"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-15-264"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1177\/0962280215588241"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2015.11.005"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/ebm.12.5.149"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.10.1092"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e318160d093"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(88)90072-9"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136\/bmj"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1159\/000097073"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.homp.2015.02.004"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2016.01.005"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0000000000000322"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.2147\/PROM.S156279"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keh152"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2015.1059424"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2014.0473"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1037\/a0036317"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003592"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2012.04.029"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.beth.2008.12.005"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2011.11.009"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.11.1851"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5545.102424"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2016.0232"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2017.19.2\/rparikh"}],"container-title":["Complementary Medicine Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514524","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514524","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:25:19Z","timestamp":1745425519000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000514524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":38,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,10,7]]},"published-print":{"date-parts":[[2021,10,21]]}},"URL":"https:\/\/doi.org\/10.1159\/000514524","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.14159615","asserted-by":"subject"}]},"ISSN":["2504-2092","2504-2106"],"issn-type":[{"value":"2504-2092","type":"print"},{"value":"2504-2106","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}