{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T20:16:34Z","timestamp":1770754594379,"version":"3.50.0"},"reference-count":10,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2020]]},"abstract":"<b><i>Introduction:<\/i><\/b> Saliva problems are common and distressing for people with motor neuron disease (pwMND). Despite clinical guidelines for assessment and treatment, management of saliva problems has received little research attention. <b><i>Objective:<\/i><\/b> We aimed to investigate the prevalence of saliva problems in pwMND, their association with clinical factors, and their management practice using a highly curated population-based register for motor neuron disease (MND) with 99% case ascertainment. <b><i>Methods:<\/i><\/b> We conducted an analysis of pwMND diagnosed between January 2015 and October 2019 using the Scottish MND Register (CARE-MND [Clinical, Audit, Research, and Evaluation of MND]). The association between clinical factors and saliva problems was investigated using univariate and multivariable logistic regression; results are reported as odds ratio (OR) and 95% confidence intervals. A survey of health-care professionals involved in the care of pwMND was performed to contextualize the findings. <b><i>Results:<\/i><\/b> 939 pwMND were included. Prevalence of saliva problems was 31.3% (294). Bulbar onset (OR 9.46 [4.7, 19.2]; <i>p<\/i> &#x3c; 0.001) but not age, sex, time to diagnosis, or MND subtype were independently associated with the presence of saliva problems in multivariable regression, and 52.7% (155) of those with saliva problems received pharmacological management. The most commonly used medications were hyoscine, amitriptyline, carbocisteine, glycopyrrolate, and atropine. Evidence base (8, 72.7%) and local guidelines (10, 90.9%) were cited as the most important factors influencing treatment decision by survey respondents (<i>n<\/i> = 11). <b><i>Conclusion:<\/i><\/b> Saliva problems are common and associated with bulbar onset MND. A substantial proportion of pwMND with saliva problems did not receive recommended treatments. Future research is required to determine the relative efficacy of individual pharmacological treatments. <\/jats:p>","DOI":"10.1159\/000514615","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T21:03:36Z","timestamp":1619471016000},"page":"147-152","source":"Crossref","is-referenced-by-count":13,"title":["The Prevalence and Management of Saliva Problems in Motor Neuron Disease: A 4-Year Analysis of the Scottish Motor Neuron Disease Register"],"prefix":"10.1159","volume":"20","author":[{"given":"Iona","family":"Pearson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella A.","family":"Glasmacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Newton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Beswick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arpan R.","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Davenport","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddharthan","family":"Chandran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suvankar","family":"Pal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"CARE-MND consortium","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,4,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2147\/dnnd.s168353"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2015.1131831"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/mus.22305"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09190-7"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-510x(99)00210-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2017.1386688"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12559"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.06.016"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.11.230"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3109\/21678421.2012.735238"}],"container-title":["Neurodegenerative Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514615","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:26:30Z","timestamp":1745425590000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000514615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,5,11]]},"published-print":{"date-parts":[[2021,5,18]]}},"URL":"https:\/\/doi.org\/10.1159\/000514615","archive":["Portico"],"relation":{},"ISSN":["1660-2854","1660-2862"],"issn-type":[{"value":"1660-2854","type":"print"},{"value":"1660-2862","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]}}}