{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:30:48Z","timestamp":1747193448954,"version":"3.40.5"},"reference-count":16,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Background:<\/i><\/b> Nomograms can help in estimating the nodal status among clinically node-negative patients. Yet their validity in external cohorts over time is unknown. If the nodal stage can be estimated preoperatively, the need for axillary dissection can be decided. <b><i>Objectives:<\/i><\/b> The aim of this study was to validate three existing nomograms predicting 4 or more axillary lymph node metastases. <b><i>Method:<\/i><\/b> The risk for \u22654 lymph node metastases was calculated for n = 529 eligible breast cancer patients using the nomograms of Chagpar et al. [Ann Surg Oncol. 2007;14:670\u20137], Katz et al. [J Clin Oncol. 2008;26(13):2093\u20138], and Meretoja et al. [Breast Cancer Res Treat. 2013;138(3):817\u201327]. Discrimination and calibration were calculated for each nomogram to determine their validity. <b><i>Results:<\/i><\/b> In this cohort, the AUC values for the Chagpar, Katz, and Meretoja models were 0.79 (95% CI 0.74\u20130.83), 0.87 (95% CI 0.83\u20130.91), and 0.82 (95% CI 0.76\u20130.86), respectively, showing good discrimination between patients with and without high nodal burdens. <b><i>Conclusion:<\/i><\/b> This study presents support for the use of older breast cancer nomograms and confirms their current validity in an external population. <\/jats:p>","DOI":"10.1159\/000514616","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T21:08:50Z","timestamp":1617052130000},"page":"397-401","source":"Crossref","is-referenced-by-count":1,"title":["Are Breast Cancer Nomograms Still Valid to Predict the Need for Axillary Dissection?"],"prefix":"10.1159","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3426-8470","authenticated-orcid":false,"given":"Vilma","family":"Madekivi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antti","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pia","family":"Bostr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eeva","family":"Salminen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,3,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.11470"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2012.00125"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s12609-013-0137-5"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-017-3535-7"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3617-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2016.71.0947"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.9479"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-013-2468-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2020.1736332"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71116-7"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1245\/aso.2003.03.015"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2010.06.008"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1245\/aso.2003.05.020"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1177\/1533033818785032"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23992"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-012-2360-6"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514616","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514616","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:26:30Z","timestamp":1745425590000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000514616"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":16,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,5,27]]},"published-print":{"date-parts":[[2021,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000514616","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.14192081","asserted-by":"subject"}]},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"type":"print","value":"0030-2414"},{"type":"electronic","value":"1423-0232"}],"subject":[],"published":{"date-parts":[[2021]]}}}