{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T09:19:16Z","timestamp":1769246356709,"version":"3.49.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Background:<\/i><\/b> No epidemiologic study has previously reported on the associations among Beh\u00e7et\u2019s disease (BD) and autoimmune disorders. <b><i>Objectives:<\/i><\/b> To investigate the association between BD and the autoimmune disorders multiple sclerosis and rheumatoid arthritis. <b><i>Methods:<\/i><\/b> Medical records of patients newly diagnosed with BD (<i>n<\/i> = 6,214) in 2012\u20132017 were analyzed using data entered into a large, nationwide database from 2007 to 2017. An age- and sex-matched control population of individuals without BD was sampled at a ratio of controls:BD cases of 3:1 (<i>n<\/i> = 18,642). Both cohorts were analyzed for the presence of multiple sclerosis or rheumatoid arthritis within a minimum of 5 years prior to their BD diagnosis. <b><i>Results:<\/i><\/b> Patients with BD had significantly higher odds ratios (ORs) for multiple sclerosis (8.85 [95% CI 2.36\u201333.17]) and rheumatoid arthritis (4.62 [95% CI 3.35\u20136.35]) than the control group after adjustment for diabetes mellitus, hypertension, and dyslipidemia. BD patients aged &#x3c;40 years had a higher proportion of rheumatoid arthritis (OR 23.91, 95% CI 5.50\u2013103.9) than older patients (OR 3.96, 95% CI 2.83\u20135.54). <b><i>Conclusion:<\/i><\/b> Our results suggest that BD is associated with multiple sclerosis and rheumatoid arthritis. <\/jats:p>","DOI":"10.1159\/000514634","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T22:01:22Z","timestamp":1641592882000},"page":"86-91","source":"Crossref","is-referenced-by-count":5,"title":["Beh\u00e7et\u2019s Disease Is Associated with Multiple Sclerosis and Rheumatoid Arthritis: A Korean Population-Based Study"],"prefix":"10.1159","volume":"238","author":[{"given":"Jin\u00a0Hyung","family":"Jung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung\u00a0Do","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8642-2479","authenticated-orcid":false,"given":"Young\u00a0Bok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u00a0Gyu","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew486"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14601"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.002"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-015-0502-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.035"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.04.106"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/0-306-48382-3_35"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.11.996"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2017.1327967"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/2251-6581-13-18"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-006-0541-z"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/0-306-48382-3_64"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s100670070020"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0030297"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/art.27584"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852912000247"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4800(03)80004-7"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2011.04.001"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2011.06.003"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2014.05.002"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15708"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514634","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514634","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:26:39Z","timestamp":1745425599000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000514634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,23]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1,7]]},"published-print":{"date-parts":[[2022,1,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000514634","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.14267552","asserted-by":"subject"}]},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,23]]}}}