{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:12:20Z","timestamp":1761948740914,"version":"3.40.5"},"reference-count":20,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["GE Port J Gastroenterol"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; The first presentation of ulcerative colitis may be an acute flare in about 15% of patients, requiring hospital admission. In acute severe steroid-refractory ulcerative colitis, cytomegalovirus (CMV) should be sought because it is a frequent cause of refractory disease. Herpes simplex colitis constitutes a rarer event in ulcerative colitis patients and it is usually associated with immunosuppression. &lt;b&gt;&lt;i&gt;Case Presentation:&lt;\/i&gt;&lt;\/b&gt; We report a case of a first presentation of ulcerative colitis complicated by CMV and herpes simplex type 2 coinfection. After a long period of systemic corticosteroids, the diagnosis of both CMV and herpes colitis was made. Despite antiviral treatment, colectomy was required due to a contained perforation. &lt;b&gt;&lt;i&gt;Discussion\/Conclusion:&lt;\/i&gt;&lt;\/b&gt; This report highlights the importance of a high degree of suspicion for opportunistic infections in steroid\/immunomodulator refractory ulcerative colitis, even in the first flare. <\/jats:p>","DOI":"10.1159\/000514715","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T22:00:41Z","timestamp":1641333641000},"page":"56-60","source":"Crossref","is-referenced-by-count":5,"title":["Colitis due to Cytomegalovirus and Herpes Simplex Type 2 as a Complication of a First Presentation of Inflammatory Bowel Disease"],"prefix":"10.1159","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0604-2290","authenticated-orcid":false,"given":"Tiago","family":"Leal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Arroja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalila","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o\u00a0Bruno","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx008"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81891-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2003.007385"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.12.013"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2007.06.004"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2006.02460.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.01.012"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61908-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07456.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/gut.11.1.18"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.43207"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000675"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21877"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000361"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03949.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13124"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.45629-0"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/gut.27.12.1419"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/BF01297124"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2017.087"}],"container-title":["GE - Portuguese Journal of Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514715","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:27:04Z","timestamp":1745425624000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000514715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,23]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1,4]]},"published-print":{"date-parts":[[2022,1,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000514715","archive":["Portico"],"relation":{},"ISSN":["2341-4545","2387-1954"],"issn-type":[{"type":"print","value":"2341-4545"},{"type":"electronic","value":"2387-1954"}],"subject":[],"published":{"date-parts":[[2021,3,23]]}}}