{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:12:32Z","timestamp":1787839952759,"version":"build-2784847793"},"reference-count":27,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; The natural history and prognosis of superficial nonampullary duodenal epithelial tumors (SNADETs) remain uncertain. We elucidated the relationship between immunophenotype and clinicopathological features. &lt;b&gt;&lt;i&gt;Materials and Methods:&lt;\/i&gt;&lt;\/b&gt; A total of 98 SNADETs were divided into 3 groups according to immunohistochemical findings: gastric phenotype (G type), gastrointestinal phenotype (GI type), and intestinal phenotype (I type). Cellular dysplasia was divided into low-grade dysplasia and high-grade dysplasia\/adenocarcinoma (\u2265HGD). White opaque substance (WOS) deposition was categorized into diffuse WOS, partial WOS, and no WOS, based on endoscopic findings. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Of the 98 SNADETs, 4 lesions (4.1%) were G type, 32 lesions (32.7%) were GI type, and 62 lesions (63.2%) were I type. All G-type SNADETs were located in the oral side of the papilla including the bulb, and the rate of bulbar lesions was significantly higher in the G type than in the GI and I types (&lt;i&gt;p&lt;\/i&gt; = 0.004). The most frequent type of WOS was no WOS (4\/4, 100%) for G type, partial WOS (19\/32, 59.4%) for GI type, and diffuse WOS (34\/62, 54.8%) for I type (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001), and loss of intestinal character was significantly correlated with WOS deficiency. GI\/I-type SNADETs with partial or no WOS and G-type SNADETs were associated with \u2265HGD. Additionally, the frequency of \u2265HGD lesion was significantly higher in the CD10-negative group than in the CD10-positive group (57.1 vs. 19.8%, &lt;i&gt;p&lt;\/i&gt; = 0.043). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Pathological intestinal character was correlated with the presence of WOS, and CD10 loss was associated with malignant potential of SNADETs. <\/jats:p>","DOI":"10.1159\/000514812","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T21:00:39Z","timestamp":1617310839000},"page":"870-877","source":"Crossref","is-referenced-by-count":11,"title":["Relationship between Immunophenotype and Clinicopathological Findings for Superficial Nonampullary Duodenal Epithelial Tumor"],"prefix":"10.1159","volume":"102","author":[{"given":"Shigeki","family":"Fukusada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6048-0021","authenticated-orcid":false,"given":"Takaya","family":"Shimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyasu","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Okuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahito","family":"Katano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruriko","family":"Nishigaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Ozeki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotada","family":"Nishie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Ozeki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Tanida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9491-0723","authenticated-orcid":false,"given":"Hiromi","family":"Kataoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,4,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3109\/00365529409092458"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1021475"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/den.12277"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/den.12259"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/den.12104"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.clcc.2016.09.009"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1339"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2152\/jmi.54.99"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.01.003"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000508040"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174985"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181577511"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5107(03)02159-x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.04.011"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04505.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.2.251"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-017-1327-0"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2007.02.013"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2012.01314.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2012.01364.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000485505"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/den.13538"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.4132\/KoreanJPathol.2013.47.4.340"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117526"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1002\/pros.10202"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000168"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i9.2700"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514812","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514812","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:27:38Z","timestamp":1745425658000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000514812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":27,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,11,3]]},"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