{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:46:35Z","timestamp":1791229595361,"version":"4.1.0"},"reference-count":30,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Cytologica"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Introduction:&lt;\/i&gt;&lt;\/b&gt; Thyroid cytology is a widely accepted tool in the clinical triaging of nodular lesions. Cell blocks (CBs) can help in the diagnosis of atypical lesions, namely, thyroid Bethesda category of Atypia of undetermined significance\/follicular lesion of undetermined significance (AUS\/FLUS). &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; In a series of 224 AUS\/FLUS thyroid samples with CB, we studied CB cellularity and feasibility of 3 immunohistochemical markers (cytokeratin 19 [CK19], HBME-1, and galectin-3) apart and in combination. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The CBs were non-diagnostic in 34 cases. Twenty-four CBs contained &amp;#x3c;10 cells, 45 CBs 10\u201350 cells, and 121 CBs &amp;#x3e;50 cells. Notably, more cellularity was found in CBs performed by plasma-thrombin and in-house techniques (&lt;i&gt;p&lt;\/i&gt; &amp;#x3c; 0.001). The diagnostic accuracy to detect malignancy was 65.1% for CK19, 72.1% for HBME-1, and 70.3% for galectin-3. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; In conclusion, CB cellularity is essential for successful immunohistochemistry application and further diagnostic workup of AUS\/FLUS cases. <\/jats:p>","DOI":"10.1159\/000514906","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T21:00:41Z","timestamp":1617224441000},"page":"257-263","source":"Crossref","is-referenced-by-count":10,"title":["The Role of Cell Blocks and Immunohistochemistry in Thyroid Atypia of Undetermined Significance\/Follicular Lesion of Undetermined Significance Bethesda 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