{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T10:17:02Z","timestamp":1775211422870,"version":"3.50.1"},"reference-count":19,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; The objective of our study was to assess the utility of sequential fetal urine analysis in severe lower urinary tract obstruction (LUTO) when selecting cases suitable for vesicoamniotic shunting. &lt;b&gt;&lt;i&gt;Material and Methods:&lt;\/i&gt;&lt;\/b&gt; This was a retrospective cohort study of cases of severe LUTO treated in our fetal medicine center from 1994 to 2013. Two fetal bladder samples were taken 24\u201348 h apart to assess renal function. A vesicoamniotic shunt was inserted in case of improvement in urinary biochemistry between the 2 samples. We assessed perinatal morbidity and mortality and renal function at 5 years. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Among a total of 26 LUTO cases with sequential urine analysis, 5 showed normal urinary biochemistry, 13 were abnormal, and 8 improved between the 2 samples. These 8 cases underwent vesicoamniotic shunt placement, leading to the birth of 6\/8 (75%) live infants, 5\/6 (83%) of whom had normal renal function at 5 years. The 5 cases with normal biochemistry occasioned 2 neonatal deaths and 3 children with normal renal function at 5 years. Elective termination of pregnancy was requested by parents for the fetuses exhibiting abnormal biochemistry. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; An improvement in urinary biochemistry between 2 sequential fetal bladder punctures in severe LUTO could be an effective criterion in the selection of candidates for vesicoamniotic shunting. However, the benefit of a shunt in fetuses with normal amniotic fluid remains to be evaluated in clinical trials. <\/jats:p>","DOI":"10.1159\/000514911","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T05:55:57Z","timestamp":1617083757000},"page":"265-271","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of Sequential Urine Analysis when Selecting Candidates for Vesicoamniotic Shunting in Lower Urinary Tract Obstruction"],"prefix":"10.1159","volume":"48","author":[{"given":"Antoine","family":"Koch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romain","family":"Favre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Sophie","family":"Weingertner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariane","family":"Zaloszyc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"Kohler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Rosenblatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Muller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Dreux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Sanan\u00e8s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1074"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-017-3593-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2009.03.010"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14808"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000367805"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15988"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.02.011"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19172"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4958"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00167.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(95)90928-1"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/pd.90"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5359"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90170-1"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2736"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.01640309"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60992-7"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005807"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-015-3246-8"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514911","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/514911","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:28:48Z","timestamp":1745425728000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000514911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4,19]]},"published-print":{"date-parts":[[2021,5,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000514911","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}