{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T12:57:47Z","timestamp":1775739467164,"version":"3.50.1"},"reference-count":25,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Background:<\/i><\/b> The diagnostic yield of peripheral pulmonary lesions (PPLs) using radial endobronchial ultrasound (EBUS) remains challenging without navigation systems. Cone-beam computed tomography-derived augmented fluoroscopy (CBCT-AF) represents a recently developed technique, and its clinical utility remains to be investigated. <b><i>Objectives:<\/i><\/b> The aim of this study was to investigate the diagnostic yield of transbronchial biopsy (TBB) using a combination of CBCT-AF and radial EBUS. <b><i>Methods:<\/i><\/b> We recruited consecutive patients with PPLs who underwent radial EBUS-guided TBB, with or without AF, between October 2018 and July 2019. Following propensity score 1:1 matching, we recorded the procedure-related data and measured their efficacy and safety. <b><i>Results:<\/i><\/b> While 72 patients received EBUS-plus-AF, 235 patients received EBUS only. We included 53 paired patients following propensity score matching. The median size of lesions was 2.8 and 2.9 cm in the EBUS-plus-AF group and EBUS-only group, respectively. Diagnostic yield was higher in the former group (75.5 vs. 52.8%; <i>p<\/i> = 0.015). The diagnostic yield for the EBUS-plus-AF group was significantly higher for lesions \u226430 mm (73.5 vs. 36.1%; <i>p<\/i> = 0.002). Moreover, there was no significant difference in the complication rates (3.8 vs. 5.7%; <i>p<\/i> = 1.000). Twenty-four nodules (45.3%) were invisible by fluoroscopy in the EBUS-plus-AF group. All of them were identifiable on CBCT images and successfully annotated for AF. The mean radiation dose of total procedure, CBCT, and fluoroscopy was 19.59, 16.4, and 3.17 Gy cm<sup>2<\/sup>, respectively. <b><i>Conclusions:<\/i><\/b> TBB using a combination of CBCT-AF and EBUS resulted in a satisfactory diagnostic yield and safety. <\/jats:p>","DOI":"10.1159\/000515181","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T21:00:31Z","timestamp":1618261231000},"page":"538-546","source":"Crossref","is-referenced-by-count":29,"title":["Efficacy and Safety of Cone-Beam Computed Tomography-Derived Augmented Fluoroscopy Combined with Endobronchial Ultrasound in Peripheral Pulmonary Lesions"],"prefix":"10.1159","volume":"100","author":[{"given":"Kai-Lun","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun-Mao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan-Jang","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Yu","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jen-Chung","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Kai","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao-Chi","family":"Ho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Yuan","family":"Shih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,4,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2017161659"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.47.7.565"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.6.1500"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.02.00032001"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1378\/chest.126.3.959"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12980"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2072-1439.2015.12.16"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201502-0205OC"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1378\/chest.72.4.474"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.198.3.8628859"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200603-344OC"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00165306"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2020-000595"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2008.02.002"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/lbr.0000000000000536"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24300-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.1.382"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.145490"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-017-0403-9"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2016.11.037"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2017.02.035"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.11.21"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10091269"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2020.03.85"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2020.01.35"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/515181","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/515181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:31:09Z","timestamp":1745425869000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000515181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":25,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,6,3]]},"published-print":{"date-parts":[[2021,6,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000515181","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}