{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T09:17:23Z","timestamp":1759742243422,"version":"3.40.4"},"reference-count":37,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Background:<\/i><\/b> Angiogenesis in non-Hodgkin lymphoma (NHL) has been investigated by a variety of studies. However, the correlation between angiogenesis and the occurrence or prognosis of NHL patients remains controversial. <b><i>Methods:<\/i><\/b> We performed a systematic and comprehensive retrieval of relevant literatures from PubMed, EMBASE, and Web of Science databases. The quality of the eligible studies was assessed using the Newcastle-Ottawa Scale (NOS). <b><i>Results:<\/i><\/b> Fifteen eligible studies containing a total of 1373 NHL patients were included in this study. All the eligible studies were high-quality studies scoring \u22656 points. MVD was not different between NHL and control (SMD = 0.281, 95% CI: \u22121.410 to 1.972, <i>p<\/i> = 0.745). High MVD was associated with advanced disease stage (OR = 1.580, 95% CI: 1.080\u20132.311, <i>p<\/i> = 0.018) and unfavorable OS (HR = 1.656, 95% CI: 1.366\u20132.009, <i>p<\/i> = 0.000) but not with PFS (HR = 1.349, 95% CI: 0.852\u20132.136, <i>p<\/i> = 0.201). <b><i>Conclusion:<\/i><\/b> This meta-analysis demonstrated that high MVD was related to advanced disease stage and associated with unfavorable OS of NHL patients. <\/jats:p>","DOI":"10.1159\/000515211","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T21:01:04Z","timestamp":1622149264000},"page":"603-612","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic Value of Microvessel Density in Non-Hodgkin Lymphoma: A 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