{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:40:01Z","timestamp":1792842001652,"version":"4.5.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Objective:<\/i><\/b> To determine whether nasal high-frequency oscillatory ventilation (NHFOV) as a primary mode of respiratory support as compared with nasal continuous airway pressure (NCPAP) will reduce the need for invasive mechanical ventilation in preterm infants (26<sup>0\/7<\/sup>\u201333<sup>6\/7<\/sup> weeks of gestational age [GA]) with respiratory distress syndrome (RDS). <b><i>Methods:<\/i><\/b> This multicenter randomized controlled trial was conducted in 18 tertiary neonatal intensive care units in China. A total of 302 preterm infants born at a GA of 26<sup>0\/7<\/sup>\u201333<sup>6\/7<\/sup> weeks with a diagnosis of RDS were randomly assigned to either the NCPAP (<i>n<\/i> = 150) or the NHFOV (<i>n<\/i> = 152) group. The primary outcome was the need for invasive mechanical ventilation during the first 7 days after birth. <b><i>Results:<\/i><\/b> Treatment failure occurred in 15 of 152 infants (9.9%) in the \u00adNHFOV group and in 26 of 150 infants (17.3%) in the NCPAP group (95% CI of risk difference: \u221215.2 to 0.4, <i>p =<\/i> 0.06). In the subgroup analysis, NHFOV resulted in a significantly lower rate of treatment failure than did NCPAP in the strata of 26<sup>+0\/7<\/sup>\u201329<sup>+6\/7<\/sup>weeks of GA (11.9 vs. 32.4%, 95% CI of risk difference: \u221239.3 to \u22121.7, <i>p =<\/i> 0.03) and birth weight &#x3c;1,500 g (10.4 vs. 29.6%, 95% CI of risk difference: \u221233.8 to \u22124.6, <i>p =<\/i> 0.01). The rate of thick secretions causing an airway obstruction was higher in the NHFOV group than in the NCPAP group (13.8 vs. 5.3%, 95% CI of risk difference: 1.9\u201315.1, <i>p =<\/i> 0.01). No significant differences in other secondary outcomes were found between the NHFOV and NCPAP groups. <b><i>Conclusions:<\/i><\/b> NHFOV was not superior to NCPAP with regard to the primary outcome when applied as the primary respiratory support for RDS in infants between 26<sup>+0\/7<\/sup> and 33<sup>+6\/7<\/sup> weeks of GA. In the subgroup analysis, NHFOV seemed to improve effectiveness than NCPAP in preterm infants &#x3c;30 weeks of GA. <\/jats:p>","DOI":"10.1159\/000515226","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T21:01:10Z","timestamp":1617829270000},"page":"325-331","source":"Crossref","is-referenced-by-count":27,"title":["Nasal High-Frequency Oscillatory Ventilation in Preterm Infants with Moderate Respiratory Distress Syndrome: A Multicenter Randomized Clinical Trial"],"prefix":"10.1159","volume":"118","author":[{"given":"Xingwang","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7358-601X","authenticated-orcid":false,"given":"Rangasamy","family":"Ramanathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the NHFOV study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,4,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.35-10-417"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000499361"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-3985"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2016-310664"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-014-2419-y"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1381317"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.0578-1310.2017.03.003"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-018-2673-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.123.7.991"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.7.2011060"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(78)80282-0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197801000-00001"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23755"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2019-000443"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23824"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2016.1243"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/515226","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/515226","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:31:52Z","timestamp":1745425912000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000515226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,7,20]]},"published-print":{"date-parts":[[2021,9,10]]}},"URL":"https:\/\/doi.org\/10.1159\/000515226","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.14380931","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}