{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:26:18Z","timestamp":1780583178388,"version":"3.54.1"},"reference-count":128,"publisher":"S. Karger AG","issue":"1-3","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sex Dev"],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:p>Animals determine their sex genetically (GSD: genetic sex determination) and\/or environmentally (ESD: environmental sex determination). Medaka (&lt;i&gt;Oryzias latipes&lt;\/i&gt;) employ a XX\/XY GSD system, however, they display female-to-male sex reversal in response to various environmental changes such as temperature, hypoxia, and green light. Interestingly, we found that 5 days of starvation during sex differentiation caused female-to-male sex reversal. In this situation, the metabolism of pantothenate and fatty acid synthesis plays an important role in sex reversal. Metabolism is associated with other biological factors such as germ cells, HPG axis, lipids, and epigenetics, and supplys substances and acts as signal transducers. In this review, we discuss the importance of metabolism during sex differentiation and how metabolism contributes to sex differentiation. <\/jats:p>","DOI":"10.1159\/000515281","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T21:00:57Z","timestamp":1626814857000},"page":"168-178","source":"Crossref","is-referenced-by-count":12,"title":["Metabolism and Sex Differentiation in Animals from a Starvation Perspective"],"prefix":"10.1159","volume":"15","author":[{"given":"Yuta","family":"Sakae","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,7,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000330120"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/6.6.554"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1178343"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ircmb.2015.05.004"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000497745"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmk003"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1530\/REP-15-0562"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/bf00691032"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.301"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jembe.2014.07.009"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2017.60"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/nature13981"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjr001"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s10646-014-1269-8"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073861"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M025403"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.01.002"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00435-13"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2013.01.016"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.12.043"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2020.103833"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqz024"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1071\/RD14383"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.06.011"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06487.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00211.2013"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap8328"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.63.02.180"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-68594-y"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-18-0108"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2019.09.003"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006548"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-38908-w"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.21203"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1620915114"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.204.2.269"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1038\/nature14574"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-88-21632"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1038\/nm1388"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2882"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-42669-x"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1111\/jeb.12480"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1101\/gad.287045.116"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2012.00028"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/490476"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.01.021"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1159\/000204090"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.22080"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1038\/nature11689"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1159\/000358892"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609932104"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2020.06.013"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn149"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1514012112"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1002\/stem.402"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1002\/stem.590"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2017.07.008"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/ict093"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2015.10.004"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14124"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.k11e-131"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2010.01.002"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2020.110971"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2020.113618"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611379104"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1159\/000342272"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjv060"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.02.002"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-2060"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1038\/nature12932"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1210\/en.2017-00808"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1242\/dev.076307"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007259"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1038\/nature05883"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.06.002"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1044"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1038\/nature08313"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2011.177"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1111\/1749-4877.12479"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-1285"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2007.0583"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.2174\/1389450118666171122141821"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2006.04.010"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3629"},{"key":"ref85","doi-asserted-by":"publisher","DOI":"10.2307\/1444818"},{"key":"ref86","doi-asserted-by":"publisher","DOI":"10.1002\/jez.10071"},{"key":"ref87","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2443.2011.01527.x"},{"key":"ref88","doi-asserted-by":"publisher","DOI":"10.2527\/1992.7041271x"},{"key":"ref89","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2019.01.003"},{"key":"ref90","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2020.111031"},{"key":"ref91","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.03.017"},{"key":"ref92","doi-asserted-by":"publisher","DOI":"10.1242\/dev.091777"},{"key":"ref93","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2008.09.025"},{"key":"ref94","doi-asserted-by":"publisher","DOI":"10.1242\/dev.147322"},{"key":"ref95","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0488"},{"key":"ref96","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217133"},{"key":"ref97","doi-asserted-by":"publisher","DOI":"10.1016\/j.anireprosci.2008.01.023"},{"key":"ref98","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7360121"},{"key":"ref99","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2768"},{"key":"ref100","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.21132"},{"key":"ref101","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000064899.53876.A3"},{"key":"ref102","doi-asserted-by":"publisher","DOI":"10.1530\/EC-20-0068"},{"key":"ref103","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.08.008"},{"key":"ref104","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.03.049"},{"key":"ref105","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag3145"},{"key":"ref106","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36674-9"},{"key":"ref107","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201899518"},{"key":"ref108","doi-asserted-by":"publisher","DOI":"10.1111\/asj.12951"},{"key":"ref109","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.08.007"},{"key":"ref110","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.01.003"},{"key":"ref111","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-1392-9"},{"key":"ref112","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinsphys.2015.02.002"},{"key":"ref113","doi-asserted-by":"publisher","DOI":"10.1038\/srep25125"},{"key":"ref114","doi-asserted-by":"publisher","DOI":"10.1002\/jat.4035"},{"key":"ref115","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00087"},{"key":"ref116","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2014.10.011"},{"key":"ref117","doi-asserted-by":"publisher","DOI":"10.1159\/000445207"},{"key":"ref118","doi-asserted-by":"publisher","DOI":"10.1126\/science.1173288"},{"key":"ref119","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201695417"},{"key":"ref120","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00498.2009"},{"key":"ref121","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz4165"},{"key":"ref122","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0228"},{"key":"ref123","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.364"},{"key":"ref124","doi-asserted-by":"publisher","DOI":"10.1038\/srep18581"},{"key":"ref125","doi-asserted-by":"publisher","DOI":"10.1038\/nature11163"},{"key":"ref126","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-009-9076-8"},{"key":"ref127","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-017-4068-9"},{"key":"ref128","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.11.015"}],"container-title":["Sexual Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/515281","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/515281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:32:31Z","timestamp":1745425951000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000515281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":128,"journal-issue":{"issue":"1-3","published-online":{"date-parts":[[2021,9,10]]},"published-print":{"date-parts":[[2021,9,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000515281","archive":["Portico"],"relation":{},"ISSN":["1661-5425","1661-5433"],"issn-type":[{"value":"1661-5425","type":"print"},{"value":"1661-5433","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]}}}