{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T15:47:02Z","timestamp":1783698422682,"version":"3.55.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2022]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; COronaVIrus Disease 2019 (COVID-19) affects children with less severe symptoms than adults. However, severe COVID-19 paediatric cases are increasingly reported, including patients with Kawasaki disease (KD) or a multisystem inflammatory syndrome (MIS-C) that can present with features resembling KD. &lt;b&gt;&lt;i&gt;Summary:&lt;\/i&gt;&lt;\/b&gt; MIS-C is an emerging severe paediatric syndrome associated with COVID-19 that can show overlapping features of KD, KD shock syndrome, and toxic shock syndrome. MIS-C might be an inflammatory disease distinct from KD resulting from an exaggerated immune response. A high prevalence of mucocutaneous manifestations \u2013 in addition to gastrointestinal and cardiovascular involvements \u2013 was found in MIS-C. The most frequent mucocutaneous findings were conjunctivitis and rash, often described as macular and\/or papular or polymorphous. In this article, we present a brief overview of MIS-C with an emphasis on mucocutaneous findings and the relationship with KD. <\/jats:p>","DOI":"10.1159\/000515449","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T21:17:09Z","timestamp":1622582229000},"page":"35-43","source":"Crossref","is-referenced-by-count":12,"title":["Multisystem Inflammatory Syndrome in Children Associated with COVID-19: A Review with an Emphasis on Mucocutaneous and Kawasaki Disease-Like Findings"],"prefix":"10.1159","volume":"238","author":[{"given":"Angelo Valerio","family":"Marzano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Cassano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Moltrasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Verdoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Genovese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gino Antonio","family":"Vena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2021,6,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1080\/20469047.2020.1781356"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1542\/hpeds.2020-0123"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31094-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31103-X"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30651-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s42399-020-00602-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2020.10.004"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00574"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-018-0536-3"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.193903"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2020.100527"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002888"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.10369"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6932e2"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.4779"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021680"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2021756"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m2094"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.19264"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000512932"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2020.06.005"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/515449","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/515449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:34:22Z","timestamp":1745426062000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000515449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,1]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1,7]]},"published-print":{"date-parts":[[2022,1,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000515449","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,1]]}}}