{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T03:31:46Z","timestamp":1747193506469,"version":"3.40.5"},"reference-count":13,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stereotact Funct Neurosurg"],"published-print":{"date-parts":[[2021]]},"abstract":"<b><i>Introduction:<\/i><\/b> Supratentorial primitive neuroectodermal tumor is a rare, aggressive intrinsic brain tumor with limited treatment options for recurrent disease. SRS as a treatment modality in the recurrent setting was investigated. <b><i>Methods:<\/i><\/b> A retrospective review of 8 patients treated with SRS for local or distant recurrence of supratentorial PNET from 1999 to 2014 was conducted. <b><i>Results:<\/i><\/b> Thirty-six tumors were treated in 15 sessions in 8 patients. The median patient age was 22.5 (interquartile range [IQR], 14.75\u201343.5 years) with a median 21-month period from diagnosis until SRS (IQR, 16\u201323.75 months). The median prescription isodose volume was 1.85 cm<sup>3<\/sup> (IQR, 1.85\u20137.02 cm<sup>3<\/sup>); median tumor margin dose was 18 Gy (IQR 14\u201320 Gy); and median isocenters was 2 (range 1\u201313). No patients experienced adverse radiation effects. All but 1 patient died, and the median overall survival was 32 months (IQR, 26.75\u201353.5 months) with median overall survival following SRS of 9.5 months (IQR, 5.25\u201330 months). Univariate analysis failed to demonstrate a statistically significant association between age, number of gamma knife treatments, interval to gamma knife, and margin radiation dose with overall survival. <b><i>Discussion\/Conclusion:<\/i><\/b> This series supports the use of SRS in patients with recurrent supratentorial PNET following multimodal therapy. <\/jats:p>","DOI":"10.1159\/000515544","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T21:03:28Z","timestamp":1619039008000},"page":"405-411","source":"Crossref","is-referenced-by-count":0,"title":["Salvage Radiosurgery for Recurrent Supratentorial Primitive Neuroectodermal Tumors: A Single Institutional Series and Review of the Literature"],"prefix":"10.1159","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4891-498X","authenticated-orcid":false,"given":"Jaclyn J.","family":"Renfrow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2896-1722","authenticated-orcid":false,"given":"Desmond A.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Link","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia N.","family":"Laack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Routman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce E.","family":"Pollock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian F.","family":"Parney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,4,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0142(19990715)86:2%3c331::aid-cncr18%3e3.0.co;2-#"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20471"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153443"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1545-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-004-4527-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000120901"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3171\/JNS\/2008\/108\/2\/0204"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000448927"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-005-9041-9"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/BF00167072"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-013-1163-x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/BF00165520"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-014-1561-8"}],"container-title":["Stereotactic and Functional Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/515544","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/515544","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:35:30Z","timestamp":1745426130000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000515544"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":13,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,8,31]]},"published-print":{"date-parts":[[2021,9,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000515544","archive":["Portico"],"relation":{},"ISSN":["1011-6125","1423-0372"],"issn-type":[{"type":"print","value":"1011-6125"},{"type":"electronic","value":"1423-0372"}],"subject":[],"published":{"date-parts":[[2021]]}}}