{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:25:56Z","timestamp":1762543556130,"version":"3.40.5"},"reference-count":25,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T00:00:00Z","timestamp":1637625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ocul Oncol Pathol"],"published-print":{"date-parts":[[2022]]},"abstract":"<b><i>Background:<\/i><\/b> Uveal melanoma is the most common primary intraocular malignancy in adults, often resulting in painless vision loss. We report a case of necrotic uveal melanoma presenting with orbital inflammation mimicking orbital cellulitis and present a comprehensive review of the literature and tabulation of reported cases. <b><i>Summary:<\/i><\/b> Our review found 44 published reports of spontaneously necrotic uveal melanoma involving 55 patients. Of these reports, 26 patients (47%) presented with orbital cellulitis. Presenting symptoms of necrotic uveal melanoma with orbital cellulitis included proptosis (82.8%), pain (80.7%), vision loss (61.5%), and restricted extraocular movements (46.2%). <b><i>Key Messages:<\/i><\/b> Uveal melanoma can rarely mimic orbital cellulitis. Autoinfarction and tumor necrosis causes secondary orbital inflammation. Intraocular malignancy must remain in the differential for patients with orbital inflammation and vision loss. <\/jats:p>","DOI":"10.1159\/000515558","type":"journal-article","created":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T22:00:52Z","timestamp":1637704852000},"page":"1-8","source":"Crossref","is-referenced-by-count":4,"title":["Necrotic Uveal Melanoma Mimics Orbital Cellulitis: A Review"],"prefix":"10.1159","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0656-546X","authenticated-orcid":false,"given":"Ahmad","family":"Abdel-Aty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy L.","family":"Linderman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ninani","family":"Kombo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Sinard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renelle","family":"Pointdujour-Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2015.10.005"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3892\/mco.2016.1037"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S89591"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1985.01050070071033"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-199001010-00013"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1991.137"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1993.117"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1995.01100120108025"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3109\/01676839609150067"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1998.77"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/00002341-199807000-00012"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1076\/orbi.18.2.123.2718"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s12009-002-0080-y"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1177\/112067210601600429"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-013-9836-1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080\/01676830.2016.1176216"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159\/000477546"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-227486"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2019.100557"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(70)91860-x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2010.11.004"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1007\/BF02159979"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197711)40:5%3c2388::aid-cncr2820400556%3e3.0.co;2-o"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11081055"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000550"}],"container-title":["Ocular Oncology and Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/515558","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/515558","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:35:43Z","timestamp":1745426143000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000515558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,23]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,2,15]]},"published-print":{"date-parts":[[2022,3,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000515558","archive":["Portico"],"relation":{},"ISSN":["2296-4681","2296-4657"],"issn-type":[{"type":"print","value":"2296-4681"},{"type":"electronic","value":"2296-4657"}],"subject":[],"published":{"date-parts":[[2021,11,23]]}}}